1: 90 percent / ethyldiisopropylamine / CH2Cl2 / 12 h / 25 °C
2: 71 percent / K2CO3 / dimethylformamide / 1 h / 70 °C
View Scheme
参考文献
Marsilje, Thomas H.; Hedrick, Michael P.; Desharnais, Joel; Tavassoli, Ali; Zhang, Yan; Wilson, Ian A.; Benkovic, Stephen J.; Boger, Dale L.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4487 - 4501
1: 0.630 g / NaBH4 / methanol / 0.5 h / -20 °C
2: 92 percent / K2CO3 / dimethylformamide / 1 h / 70 °C
3: 52 percent / sodium methoxide / methanol / 1 h / 25 °C
View Scheme
参考文献
Marsilje, Thomas H.; Hedrick, Michael P.; Desharnais, Joel; Tavassoli, Ali; Zhang, Yan; Wilson, Ian A.; Benkovic, Stephen J.; Boger, Dale L.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4487 - 4501
1: 0.473 g / NaBH4 / methanol / 0.5 h / -20 °C
2: 75 percent / K2CO3 / dimethylformamide / 1 h / 70 °C
3: 66 percent / sodium methoxide / methanol / 1 h / 25 °C
View Scheme
参考文献
Marsilje, Thomas H.; Hedrick, Michael P.; Desharnais, Joel; Tavassoli, Ali; Zhang, Yan; Wilson, Ian A.; Benkovic, Stephen J.; Boger, Dale L.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4487 - 4501
Marsilje, Thomas H.; Hedrick, Michael P.; Desharnais, Joel; Tavassoli, Ali; Zhang, Yan; Wilson, Ian A.; Benkovic, Stephen J.; Boger, Dale L.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4487 - 4501
1.1: 40 percent / pyridine / CH2Cl2 / 2 h / 25 °C
2.1: dimethylformamide / 0.75 h / 25 °C
2.2: 68 percent / K2CO3 / dimethylformamide / 18 h
View Scheme
参考文献
Marsilje, Thomas H.; Hedrick, Michael P.; Desharnais, Joel; Tavassoli, Ali; Zhang, Yan; Wilson, Ian A.; Benkovic, Stephen J.; Boger, Dale L.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4487 - 4501
