4-羟基-2,6-二甲基-5-嘧啶丙酸乙酯合成路线 （共 3 条）
反应条件
sodium ethanolate in ethanol 22 h; Heating;
参考文献
Ellingboe, John W.; Antane, Madelene; Nguyen, Thomas T.; Collini, Michael D.; Antane, Schuyler; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 4 p. 542 - 550
反应条件
1: 72 percent / POCl3, N,N-dimethylaniline / 2 h / Heating 2: 69 percent / NaHCO3 / butan-1-ol / 48 h / Heating View Scheme
参考文献
Ellingboe, John W.; Antane, Madelene; Nguyen, Thomas T.; Collini, Michael D.; Antane, Schuyler; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 4 p. 542 - 550
反应条件
1: 72 percent / POCl3, N,N-dimethylaniline / 2 h / Heating 2: 69 percent / NaHCO3 / butan-1-ol / 48 h / Heating 3: 83 percent / aq. Na2CO3, tetrakis(triphenylphosphine)palladium(0) / ethanol; toluene / 16 h / Heating 4: 73 percent / methanesulfonic acid / toluene / 24 h / Heating View Scheme
参考文献
Ellingboe, John W.; Antane, Madelene; Nguyen, Thomas T.; Collini, Michael D.; Antane, Schuyler; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 4 p. 542 - 550
