D(-)-对羟基苯甘氨酸合成路线 （共 36 条）
反应条件
1.1: dichloromethane / 0 - 20 °C 2.1: diethylamino-sulfur trifluoride / dichloromethane / 1.25 h / -78 °C 2.2: 4 h / -78 - 20 °C 3.1: selenium(IV) oxide / ethyl acetate / 1 h / 75 °C 4.1: platinum(IV) oxide; hydrogen / 3040.2 Torr 5.1: 20 wt. Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr 6.1: hydrogenchloride; water / 24 h / 90 - 100 °C View Scheme
参考文献
Chemistry - An Asian Journal, , vol. 6, # 8 p. 2022 - 2027
反应条件
1.1: thionyl chloride / 3 h / Reflux 2.1: dichloromethane / 0 - 20 °C 3.1: diethylamino-sulfur trifluoride / dichloromethane / 1.25 h / -78 °C 3.2: 4 h / -78 - 20 °C 4.1: selenium(IV) oxide / ethyl acetate / 1 h / 75 °C 5.1: platinum(IV) oxide; hydrogen / 3040.2 Torr 6.1: 20 wt. Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr 7.1: hydrogenchloride; water / 24 h / 90 - 100 °C View Scheme
参考文献
Chemistry - An Asian Journal, , vol. 6, # 8 p. 2022 - 2027
反应条件
hydrogenchloride; water T=90 - 100°C; 24 h;
参考文献
Chemistry - An Asian Journal, , vol. 6, # 8 p. 2022 - 2027
反应条件
hydrogenchloride; sodium nitrite T=0°C;
参考文献
Tetrahedron Asymmetry, , vol. 6, # 6 p. 1257 - 1260
反应条件
Bacillus licheniformis; sodium hydrogencarbonate; BASIONICreg; BC 01 in water; water-d2 T=30°C; 3 h;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 17 p. 2491 - 2498
反应条件
hydrogenchloride; acetic acid T=105°C; 22 h;
参考文献
Tetrahedron Letters, , vol. 30, # 37 p. 4987 - 4990
参考文献
Journal of Antibiotics, , vol. 29, # 9 p. 890 - 901
反应条件
1: aq. HCl 2: aq. HCl View Scheme
参考文献
Journal of Antibiotics, , vol. 29, # 9 p. 890 - 901
反应条件
penicillin G acylase; water; sodium carbonate pH=8.0; 0.333333 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 350, # 11-12 p. 1729 - 1735
反应条件
potassium phosphate buffer; Pseudomonas sp. AJ-11220 in various solvent(s) T=30°C; 2 h;
参考文献
Agricultural and Biological Chemistry, , vol. 51, # 3 p. 721 - 728
