(R)-(+)-1-Boc-2-吡咯烷甲腈合成路线 （共 2 条）
反应条件
2,4,6-trichloro-1,3,5-triazine in N,N-dimethyl-formamide 1 h;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259926 A1, 2007 ;
Location in patent: Page/Page column 9 ;
US 20070259926 A1
反应条件
1: With triethylamine; isobutyl chloroformate in dichloromethane T=-25°C; 0.75 h; 2: With ammonia in methanol; dichloromethane T=20°C; 16 h; 3: With triethylamine; trifluoroacetic anhydride in tetrahydrofuran
参考文献
University of Virginia Patent Foundation
Patent: US2012/214858 A1, 2012 ;
Location in patent: Page/Page column 30 ;
US 20120214858 A1
