1-甲氧基-2-脱氧-2-氟-3,5-二苯甲酰基-L-阿拉伯呋喃糖苷合成路线 （共 8 条）
反应条件
1.1: 81 percent / HCl / 2 h / Heating 2.1: 100 percent / Amberlyst 15 (H+ form) / dimethylformamide / 18 h / 20 °C 3.1: NaH / tetrahydrofuran / 2 h / Heating 3.2: tetrahydrofuran / 2 h / 20 °C 4.1: 39.62 g / tetrahydrofuran / 16 h / 0 °C 5.1: Ph2SiH; AIBN / dioxane / 18 h / Heating 6.1: 16.36 g / H2O; AcOH / 16 h / 20 °C 7.1: 71.1 percent / H2O; HCl / 72 h / 20 °C 8.1: 81 percent / HCl / 1 h / 20 °C 9.1: pyridine / 16 h / 20 °C View Scheme
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
反应条件
1.1: 100 percent / Amberlyst 15 (H+ form) / dimethylformamide / 18 h / 20 °C 2.1: NaH / tetrahydrofuran / 2 h / Heating 2.2: tetrahydrofuran / 2 h / 20 °C 3.1: 39.62 g / tetrahydrofuran / 16 h / 0 °C 4.1: Ph2SiH; AIBN / dioxane / 18 h / Heating 5.1: 16.36 g / H2O; AcOH / 16 h / 20 °C 6.1: 71.1 percent / H2O; HCl / 72 h / 20 °C 7.1: 81 percent / HCl / 1 h / 20 °C 8.1: pyridine / 16 h / 20 °C View Scheme
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
反应条件
1.1: NaH / tetrahydrofuran / 2 h / Heating 1.2: tetrahydrofuran / 2 h / 20 °C 2.1: 39.62 g / tetrahydrofuran / 16 h / 0 °C 3.1: Ph2SiH; AIBN / dioxane / 18 h / Heating 4.1: 16.36 g / H2O; AcOH / 16 h / 20 °C 5.1: 71.1 percent / H2O; HCl / 72 h / 20 °C 6.1: 81 percent / HCl / 1 h / 20 °C 7.1: pyridine / 16 h / 20 °C View Scheme
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
反应条件
1: Ph2SiH; AIBN / dioxane / 18 h / Heating 2: 16.36 g / H2O; AcOH / 16 h / 20 °C 3: 71.1 percent / H2O; HCl / 72 h / 20 °C 4: 81 percent / HCl / 1 h / 20 °C 5: pyridine / 16 h / 20 °C View Scheme
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
反应条件
pyridine T=20°C; Esterification; 16 h; Title compound not separated from byproducts;
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
反应条件
1: 81 percent / HCl / 1 h / 20 °C 2: pyridine / 16 h / 20 °C View Scheme
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
反应条件
1: 71.1 percent / H2O; HCl / 72 h / 20 °C 2: 81 percent / HCl / 1 h / 20 °C 3: pyridine / 16 h / 20 °C View Scheme
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
反应条件
1: 16.36 g / H2O; AcOH / 16 h / 20 °C 2: 71.1 percent / H2O; HCl / 72 h / 20 °C 3: 81 percent / HCl / 1 h / 20 °C 4: pyridine / 16 h / 20 °C View Scheme
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
