2-硝基-4-(三氟甲基)苯甲酸甲酯合成路线 （共 7 条）
反应条件
sulfuric acid T=20°C; 48 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/2342 A1, 2006 ;
Location in patent: Page/Page column 55 ;
反应条件
1: 2-nitro-α,α,α-trifluoro-p-toluic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene in DMF (N,N-dimethyl-formamide) 0.25 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide) T=0 - 20°C;
参考文献
Allison, Brett D.; Hack, Michael D.; Phuong, Victor K.; Rabinowitz, Michael H.; Rosen, Mark D.
Patent: US2005/38032 A1, 2005 ;
Location in patent: Page/Page column 27 ;
US 20050038032 A1
反应条件
conc H2SO4 in methanol
参考文献
BAYER CORPORATION
Patent: US2004/102636 A1, 2004 ;
US 20040102636 A1
反应条件
in toluene T=80°C; 16 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2006/116412 A2, 2006 ;
Location in patent: Page/Page column 223; 224 ;
WO 2006/116412 A2
反应条件
triethylamine; palladium on carbon catalyst T=100°C; P=2585.81 - 3878.71 Torr; 13 h;
参考文献
Eastman Chemical Co.
Patent: US6337418 B1, 2002 ;
Location in patent: Example 3 ;
反应条件
triethylamine; bis(triphenylphosphine)palladium(II) chloride T=60°C; P=760.228 Torr; 24 h;
参考文献
Eastman Chemical Co.
Patent: US6337418 B1, 2002 ;
Location in patent: Example 5 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate P=3102.97 Torr; 3 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/2342 A1, 2006 ;
Location in patent: Page/Page column 55-56 ;
