1-(2-氯苯基)-1-丙醇合成路线 （共 7 条）
反应条件
1: diethylzinc With N,N'-bis((R,R)-2-diethylaminocyclohexyl)oxalylamide in toluene T=20°C; 0.5 h; Inert atmosphere; 2: 2-chloro-benzaldehyde in toluene T=20°C; 24 h; Inert atmosphere; Reagent/catalyst; enantioselective reaction;
参考文献
Maleev; Gugkaeva; Tsaloev; Moskalenko; Khrustalev
Russian Chemical Bulletin, 2012 , vol. 61, # 1 p. 51 - 58
Izv. Akad. Nauk, Ser. Khim., 2012 , # 1 p. 50 - 57
反应条件
dimethylsulfide borane complex in diethyl ether 24 h; Heatingfurther reducing agents;
参考文献
Jensen, Bruce L.; Jewett-Bronson, Joanne; Hadley, Stephan B.; French, Larry G.
Synthesis, 1982 , # 9 p. 732 - 735
反应条件
1: in tetrahydrofuran T=-78 - 20°C; 0.333333 h; 2: T=20°C; 4 h;
参考文献
Inamoto, Kiyofumi; Katsuno, Mika; Yoshino, Takashi; Arai, Yukari; Hiroya, Kou; Sakamoto, Takao
Tetrahedron, 2007 , vol. 63, # 12 p. 2695 - 2711
反应条件
titanium(IV) isopropylate; C56H70N2O10S2Ti2 in toluene T=0°C; 0.5 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Zhou, Shuangliu; Chuang, Da-Wei; Chang, Shih-Ju; Gau, Han-Mou
Tetrahedron Asymmetry, 2009 , vol. 20, # 12 p. 1407 - 1412
反应条件
in diethyl ether Grignard addition;
参考文献
Kalendra, Diane M.; Sickles, Barry R.
Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1594 - 1596
反应条件
pyridinium chlorochromate in dichloromethane T=20°C; 2 h;
参考文献
Inamoto, Kiyofumi; Katsuno, Mika; Yoshino, Takashi; Arai, Yukari; Hiroya, Kou; Sakamoto, Takao
Tetrahedron, 2007 , vol. 63, # 12 p. 2695 - 2711
反应条件
1: CrO3; H2SO4 / acetone; H2O / 10 °C
2: 48percent HBr; Br2 / CH2Cl2; H2O / 35 °C
View Scheme
参考文献
Kalendra, Diane M.; Sickles, Barry R.
Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1594 - 1596
