hydrogenchloride; n-butyllithium in hexane; tert-butyl methyl ether T=-78 - -65°C; 2 h; Inert atmosphere;

1: 5-bromo-2-(2,5-dimethyl-pyrrol-1-yl)-pyridine With n-butyllithium in hexane; tert-butyl methyl ether T=-74 - -69°C; 1.25 h; 2: chloroacetic acid N-methyl-N-methoxy-amide in hexane; tert-butyl methyl ether T=-73 - -67°C; 3.33333 h;

iodine; magnesium in tetrahydrofuran

1: acetic acid / cyclohexane; water 2: iodine; magnesium / tetrahydrofuran View Scheme