5-氯-2-巯基苯并噁唑合成路线 （共 27 条）
反应条件
potassium hydroxide in ethanol 7 h; Heating / reflux;
参考文献
CRITICAL THERAPEUTICS, INC.
Patent: WO2007/146066 A2, 2007 ;
Location in patent: Page/Page column 78-79 ;
反应条件
Lawesson's reagent in xylene 3 h; Heating;
参考文献
Shridhar, D. R.; Jogibhukta, M.; Shanthan Rao, P.; Handa, Vijay K.
Synthesis, 1983 , # 11 p. 936 - 937
反应条件
pyridine 2 h; Heating;
参考文献
Lok, Roger; Leone, Ronald E.; Williams, Antony J.
Journal of Organic Chemistry, 1996 , vol. 61, # 10 p. 3289 - 3297
反应条件
1: NaOH; Na2CO3; aqueous ethanol / anschliessend mit Benzoldiazoniumchlorid 2: Na2S2O4 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 75, p. 2770
反应条件
1: Na2S2O4 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 75, p. 2770
参考文献
Journal of the American Chemical Society, , vol. 75, p. 2770
Journal of Organic Chemistry, , vol. 19, p. 758,762, 765
Journal of the American Chemical Society, , vol. 55, p. 4986,4987,4990
参考文献
Bulletin de la Societe Chimique de France, , vol. <4> 33, p. 1830
反应条件
chlorine in dichloromethane T=0 - 20°C; 4 h;
参考文献
Kablaoui, Natasha; Patel, Snahel; Shao, Jay; Demian, Douglas; Hoffmaster, Keith; Berlioz, Francioise; Vazquez, Michael L.; Moore, William M.; Nugent, Richard A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 907 - 911
反应条件
in dichloromethane; N,N-dimethyl-formamide T=20 - 25°C; 1.75 h;
参考文献
Baxter, Carl A.; Cleator, Ed; Brands, Karel M. J.; Edwards, John S.; Reamer, Robert A.; Sheen, Faye J.; Stewart, Gavin W.; Strotman, Neil A.; Wallace, Debra J.
Organic Process Research and Development, 2011 , vol. 15, # 2 p. 367 - 375
反应条件
1.1: dichloromethane; N,N-dimethyl-formamide / 1.75 h / 20 - 25 °C 2.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane; water; acetonitrile / 10.08 h / 20 - 40 °C 4.1: tetrahydrofuran / 5 - 60 °C 5.1: sodium acetate; sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 15 - 20 °C 6.1: tetrahydrofuran / 4.92 h / 20 °C / Resolution of racemate 6.2: 22.25 h / 20 °C / Resolution of racemate View Scheme
参考文献
MERCK SHARP and DOHME CORP.; MERCK SHARP and DOHME LIMITED; BAXTER, Carl, A.; CLEATOR, Edward; KRSKA, Shane, W.; SHEEN, Faye; STEWART, Gavin; STROTMAN, Neil; WALLACE, Debra, J.; WRIGHT, Timothy
Patent: WO2012/148553 A1, 2012 ;
WO 2012/148553 A1
