5-氯-2-巯基苯并噁唑合成路线 （共 27 条）
反应条件
1: chlorine / dichloromethane / 4 h / 0 - 20 °C
2: triethylamine / dichloromethane / 2 h / 20 °C
3: sodium hydroxide / methanol; water
View Scheme
参考文献
Kablaoui, Natasha; Patel, Snahel; Shao, Jay; Demian, Douglas; Hoffmaster, Keith; Berlioz, Francioise; Vazquez, Michael L.; Moore, William M.; Nugent, Richard A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 907 - 911
反应条件
1: 5-chloro-1,3-benzoxazole-2-thiol With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=0 - 20°C; Inert atmosphere;
2: morpholine With triethylamine in dichloromethane
T=0 - 20°C; Inert atmosphere;
参考文献
Stewart, Gavin W.; Baxter, Carl A.; Cleator, Ed; Sheen, Faye J.
Journal of Organic Chemistry, 2009 , vol. 74, # 8 p. 3229 - 3231
反应条件
1: CHCl3; chlorine
View Scheme
参考文献
Sam et al.
Journal of Organic Chemistry, 1958 , vol. 23, p. 1500,1502
反应条件
hydrazine hydrate in butan-1-ol
10 h; Heating;
参考文献
Swelam, Samira Abou-Srie; Abu-Bakr, Sherifa Mostafa
Heterocyclic Communications, 2008 , vol. 14, # 1-2 p. 115 - 122
反应条件
1: CHCl3; chlorine
View Scheme
参考文献
Sam et al.
Journal of Organic Chemistry, 1958 , vol. 23, p. 1500,1502
反应条件
potassium carbonate in N,N-dimethyl-formamide
1.5 h; Ambient temperature;
参考文献
Yamato, Masatoshi; Takeuchi, Yasuo; Hashigaki, Kuniko; Hirota, Takashi
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 2 p. 733 - 736
参考文献
Sam,J.; Plampin,J.N.
Journal of Pharmaceutical Sciences, 1964 , vol. 53, p. 538 - 544
