N(3)-甲基-2'-脱氧胞苷合成路线 （共 16 条）
反应条件
in methanol; N,N-dimethyl-formamide
T=70°C; 1 h; Further byproducts given;
参考文献
Yamauchi, Kiyoshi; Nakagima, Toru; Kinoshita, Masayoshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2787 - 2792
反应条件
1: 1-methylpyrrolidine / acetonitrile / 1 h / Ambient temperature
2: POCl3 / acetonitrile / 0.33 h / 0 °C
3: acetonitrile / 5.5 h / 0 °C
4: 1.45 g / acetic acid; methanol / 5 h / Ambient temperature
5: 95 percent / ethanol / 1.5 h / Ambient temperature
View Scheme
参考文献
Miah, Anwar; Reese, Colin B.; Song, Quanlai
Nucleosides and Nucleotides, 1997 , vol. 16, # 1-2 p. 53 - 65
反应条件
1: POCl3 / acetonitrile / 0.33 h / 0 °C
2: acetonitrile / 5.5 h / 0 °C
3: 1.45 g / acetic acid; methanol / 5 h / Ambient temperature
4: 95 percent / ethanol / 1.5 h / Ambient temperature
View Scheme
参考文献
Miah, Anwar; Reese, Colin B.; Song, Quanlai
Nucleosides and Nucleotides, 1997 , vol. 16, # 1-2 p. 53 - 65
反应条件
ammonia; methylamine in water
T=65°C; 1 h; deprotection reagent; Product distribution;
参考文献
Reddy, M. P.; Hanna, N. B.; Farooqui, Firdous
Tetrahedron Letters, 1994 , vol. 35, # 25 p. 4311 - 4314
反应条件
ammonia; methylamine in water
T=65°C; 1 h; deprotection reagent; Product distribution;
参考文献
Reddy, M. P.; Hanna, N. B.; Farooqui, Firdous
Tetrahedron Letters, 1994 , vol. 35, # 25 p. 4311 - 4314
反应条件
ammonia; methylamine in water
T=65°C; 1 h; deprotection reagent; Product distribution;
参考文献
Reddy, M. P.; Hanna, N. B.; Farooqui, Firdous
Tetrahedron Letters, 1994 , vol. 35, # 25 p. 4311 - 4314
