(R)-N-BOC-氮杂环丁烷-2-羧酸合成路线 （共 4 条）
反应条件
in 1,4-dioxane; water T=0 - 20°C; 1 h;
参考文献
CYTOKINETICS, INCORPORATED
Patent: WO2008/16643 A2, 2008 ;
Location in patent: Page/Page column 257 ;
反应条件
triethylamine in dichloromethane T=0°C; 3.16667 h;
参考文献
WO2004/7444 A2, ;
Page 79 ;
反应条件
sodium hydroxide in tetrahydrofuran; liq. NH3; isopropyl alcohol
反应条件
lithium borohydride; chloro-trimethyl-silane in tetrahydrofuran T=0 - 20°C; 3.5 h;
参考文献
CYTOKINETICS, INCORPORATED
Patent: WO2008/16643 A2, 2008 ;
Location in patent: Page/Page column 257-258 ;
