4-氨基-3,5-二氯吡啶合成路线 （共 19 条）
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 69, p. 673,690
反应条件
1: 4-Amino-3,5-dichloropyridine With potassium tert-butylate in toluene T=90°C; Green chemistry; 2: 3-cyclopentyloxy-4-methoxy benzoic acid chloride in toluene 1 h; RefluxGreen chemistry; Reagent/catalystTemperatureSolvent;
参考文献
Cook, David C.; Jones, Ronald H.; Kabir, Humayun; Lythgoe, David J.; McFarlane, Ian M.; Pemberton, Clive; Thatcher, Alan A.; Thompson, David M.; Walton, John B.
Organic Process Research and Development, 1998 , vol. 2, # 3 p. 157 - 168
反应条件
1: 4-Amino-3,5-dichloropyridine With cesium fluoride in dimethyl sulfoxide T=90°C; 3 h; 2: (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-imidazol-1-yl)methanone in dimethyl sulfoxide T=90 - 95°C; 6.5 h; Reagent/catalyst;
参考文献
INTERQUIM, S.A.; SALAET FERRE, Josep; MARQUILLAS OLONDRIZ, Francisco
Patent: WO2014/60464 A1, 2014 ;
Location in patent: Page/Page column 17 ;
反应条件
sodium hydride in tetrahydrofuran T=0°C; 0.5 h;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2005/26095 A1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With thionyl chloride in toluene Heating / reflux; 2: 4-Amino-3,5-dichloropyridine With sodium hydride in tetrahydrofuran 1 h; Cooling;
参考文献
PHARMACIA CORPORATION
Patent: WO2005/41864 A2, 2005 ;
Location in patent: Page/Page column 143-144 ;
反应条件
1: N,O-bis(trimethylsilyl) trifluoroacetamide; toluene-4-sulfonic acid / acetonitrile / 48 h / |Reflux 2: sodium chlorite; acetic acid; 2-methyl-but-2-ene / water; acetonitrile / 2 h / 20 - 30 °C / |Cooling with ice View Scheme
参考文献
SCINOPHARM (CHANGSHU) PHARMACEUTICAL, LTD.; CHEN, Yi-Jing; PIKUL, Stanislaw; KUO, Shen-Chun; CHU, Guo-dong
Patent: WO2013/131484 A1, 2013 ;
反应条件
nitrosyl sulfuric acid; sulfuric acid
参考文献
Sell
Journal of the Chemical Society, 1911 , vol. 99, p. 1682
反应条件
N2; potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
参考文献
GENENTECH, INC.
Patent: US2011/46066 A1, 2011 ;
反应条件
peracetic acid in chloroform
T=20°C; 48 h;
参考文献
GLENMARK PHARMACEUTICALS S.A.
Patent: WO2006/64355 A2, 2006 ;
Location in patent: Page/Page column 98 ;
