4-氯-3-硝基-5-氨磺酰基苯甲酸合成路线 （共 8 条）
反应条件
1: thionyl chloride / 50 °C 2: acetonitrile / 20 °C 3: water; ammonium chloride; iron / ethanol / 2.05 h / 85 °C 4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C 5: borane-THF / tetrahydrofuran / 1 h / 20 °C 6: sodium hydroxide; water / methanol / 2 h / 50 °C View Scheme
参考文献
NEUROTHERAPEUTICS PHARMA, INC.; WANASKI, Stephen; COLLINS, Stephen; KINCAID, John
Patent: WO2012/18635 A2, 2012 ;
WO 2012/018635 A2
反应条件
sulfuric acid; sodium hydrogencarbonate; sodium hydrogensulfite in ethanol; water
反应条件
1.1: sodium hydrogencarbonate / water / 85 °C 1.2: 20 °C 2.1: zinc; ammonium chloride; methanol / tetrahydrofuran / 20 °C / Inert atmosphere View Scheme
参考文献
NEUROTHERAPEUTICS PHARMA, INC.; WANASKI, Stephen; COLLINS, Stephen; KINCAID, John
Patent: WO2012/18635 A2, 2012 ;
WO 2012/018635 A2
反应条件
sodium hydrogencarbonate in water T=85°C; 15 h;
参考文献
CONCERT PHARMACEUTICALS INC.; Tung, Roger
Patent: US2014/128469 A1, 2014 ;
Location in patent: Paragraph 0110; 0111 ;
参考文献
Ciba-Geigy Corporation
Patent: US3939267 A1, 1976 ;
Title/Abstract Full Text Show Details
Ciba-Geigy Corporation
Patent: US3982018 A1, 1976 ;
Title/Abstract Full Text Show Details
Ciba-Geigy Corporation
Patent: US3992440 A1, 1976 ;
参考文献
Ciba-Geigy Corporation
Patent: US3992440 A1, 1976 ;
反应条件
1.1: sodium hydrogencarbonate / water / 85 °C
1.2: 20 °C
2.1: thionyl chloride / 50 °C
View Scheme
参考文献
CONCERT PHARMACEUTICALS INC.; Tung, Roger
Patent: US2014/128469 A1, 2014 ;
反应条件
1.1: sodium hydrogencarbonate / water / 85 °C
1.2: 20 °C
2.1: thionyl chloride / 50 °C
3.1: acetonitrile / 20 °C
View Scheme
参考文献
NEUROTHERAPEUTICS PHARMA, INC.; WANASKI, Stephen, P.; COLLINS, Stephen, D.; KINCAID, John; DODSON, Gary, Steven
Patent: WO2013/59648 A1, 2013 ;
