(3-三氟甲基苯氧基)乙酸乙酯合成路线 （共 10 条）
反应条件
potassium carbonate; sodium iodide in acetone 3 h; Heating;
参考文献
American Cyanamid Company
Patent: US4297516 A1, 1981 ;
反应条件
sodium iodide; potassium carbonate in acetone
参考文献
Ono Pharmaceutical Co., Ltd.
Patent: US3978229 A1, 1976 ;
反应条件
sodium iodide in acetone
参考文献
Ono Pharmaceutical Company
Patent: US4065632 A1, 1977 ;
反应条件
1.1: sodium hydride / toluene; various solvent(s) / 0.08 h 1.2: 86 percent / iodine / toluene; various solvent(s) / 16 h / 20 °C 2.1: 48 percent / potassium carbonate / acetone / 16 h / Heating 3.1: triethylamine; potassium carbonate; hydrogen / Pd/C / ethyl acetate / 2 h View Scheme
参考文献
Selliah, Robert; Dantanarayana, Anura; Haggard, Karen; Egan, Judith; Do, Ernest U.; May, Jesse A.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, # 3 p. 173 - 183
反应条件
potassium hydroxide in water 1 h; Heating;
参考文献
Roussel Uclaf
Patent: US5064861 A1, 1991 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane
参考文献
Ono Pharmaceutical Company
Patent: US4065632 A1, 1977 ;
反应条件
1: NaOH / acetone / 2 h / 20 °C
2: 90 percent / SOCl2
View Scheme
参考文献
Wang, Wei; He, Hong-Wu; Zuo, Na; Zhang, Xin; Lin, Ji-Sheng; Chen, Wei; Peng, Hao
Journal of Fluorine Chemistry, 2012 , vol. 142, p. 24 - 28
反应条件
1: 90 percent / diisobutylaluminium hydride / diethyl ether / -70 °C
2: 1) ethylbromide, Mg / 1) THF, colling with ice; 2) THF, 18 h, room temp.
3: 93 percent / imidazole / dimethylformamide / 1) 5 gradC, 1.5 h; 2) room temp., 18 h
View Scheme
参考文献
Tolstikov, G. A.; Miftakhov, M. S.; Danilova, N. A.; Galin, F. Z.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 1624 - 1631
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 9 p. 1857 - 1866
反应条件
1: 90 percent / diisobutylaluminium hydride / diethyl ether / -70 °C
2: 1) ethylbromide, Mg / 1) THF, colling with ice; 2) THF, 18 h, room temp.
View Scheme
参考文献
Tolstikov, G. A.; Miftakhov, M. S.; Danilova, N. A.; Galin, F. Z.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 1624 - 1631
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 9 p. 1857 - 1866
反应条件
diisobutylaluminium hydride in diethyl ether
T=-70°C;
参考文献
Tolstikov, G. A.; Miftakhov, M. S.; Danilova, N. A.; Galin, F. Z.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 1624 - 1631
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 9 p. 1857 - 1866
