9-苄基-9-氮杂双环[3.3.1]壬烷-3-酮合成路线 （共 5 条）
反应条件
1: 35 percent / t-BuOK / 1,2-dimethoxy-ethane; ethanol / 10 h / 50 °C 2: 80.4 percent / HCl(gas), H2O / 14 h / Heating 3: ammonium formate / 10percent Pd/C / ethanol / 4 h / Heating View Scheme
参考文献
Lowe III; Drozda; McLean; Bryce; Crawford; Snider; Longo; Nagahisa; Tsuchiya
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2831 - 2840
反应条件
1: 80 percent / 80percent N2H4*H2O, 85percent KOH / bis-(2-hydroxy-ethyl) ether 2: 67 percent / H2 / 10percent Pd/C, di-μ-chlorobis(π-allyl)dipalladium / ethanol / 40 h / 95 °C / 95000.1 Torr View Scheme
参考文献
Hayashi, Tamio; Sawamura, Masaya; Ito, Yoshihiko
Tetrahedron, 1992 , vol. 48, # 11 p. 1999 - 2012
反应条件
1: HCl
2: LiBH4
View Scheme
参考文献
Yang, Biao; Johnston Jr., Douglas E.; Luedtke, Robert R.; Hammond, Philip S.; Mach, Robert H.
Medicinal Chemistry Research, 1998 , vol. 8, # 3 p. 115 - 131
反应条件
1: sodium azide; sulfuric acid / chloroform / 2 h / -5 - 35 °C / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
NEUROSCIENZE PHARMANESS S.C. A.R.L.
Patent: US2011/152238 A1, 2011 ;
反应条件
potassium hydroxide; hydrazine hydrate in diethylene glycol
参考文献
Hayashi, Tamio; Sawamura, Masaya; Ito, Yoshihiko
Tetrahedron, 1992 , vol. 48, # 11 p. 1999 - 2012
