5,5-二甲基-1,3-噻唑烷-3-鎓-4-羧酸酯合成路线 （共 4 条）
反应条件
in water T=0 - 20°C; 23 h;
参考文献
McElroy, Andrew B.; Clegg, Stephen P.; Deal, Martyn J.; Ewan, Georg B.; Hagan, Russell M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 14 p. 2582 - 2591
反应条件
hydrogenchloride in isopropyl alcohol T=60°C; 2 h;
参考文献
Martens; Gunther; Schickedanz
Archiv der Pharmazie, 1986 , vol. 319, # 5 p. 461 - 465
反应条件
1: With Klebsiella oxytoca hydrolase in water T=60°C; 26 h; 2: With sodium hydroxide pH=11.5; Title compound not separated from byproducts;
参考文献
Ikunaka, Masaya; Matsumoto, Jun; Nishimoto, Yukifumi
Tetrahedron Asymmetry, 2002 , vol. 13, # 11 p. 1201 - 1208
反应条件
in sodium hydroxide T=0 - 20°C; 22 h;
参考文献
McElroy, Andrew B.; Clegg, Stephen P.; Deal, Martyn J.; Ewan, Georg B.; Hagan, Russell M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 14 p. 2582 - 2591
