1: 1-(2,4-dichlorophenyl)-1-hydroxy-2-(imidazol-1-yl)-ethane With N,N,N',N',N'',N''-hexamethylphosphoric triamide; sodium hydride in tetrahydrofuran T=20°C; Substitution; 0.5 h; 2: 1-(chloromethyl)-2,4-dichlorobenzene in tetrahydrofuran T=45°C; Substitution; 16 h;

1.1: 82 percent / aq. KOH / acetonitrile / 3 h / 60 °C 2.1: 63 percent / pyridine / ethanol / 12 h / Heating 3.1: NaH; HMPA / tetrahydrofuran / 0.5 h / 20 °C 3.2: 73 percent / tetrahydrofuran / 16 h / 45 °C View Scheme

1.1: 63 percent / pyridine / ethanol / 12 h / Heating 2.1: NaH; HMPA / tetrahydrofuran / 0.5 h / 20 °C 2.2: 73 percent / tetrahydrofuran / 16 h / 45 °C View Scheme