2,6-二氟-3-碘苯甲酸合成路线 （共 7 条）
反应条件
N-iodo-succinimide; trifluorormethanesulfonic acid T=0°C; 4 h;
参考文献
Sato, Motohide; Kawakami, Hiroshi; Motomura, Takahisa; Aramaki, Hisateru; Matsuda, Takashi; Yamashita, Masaki; Ito, Yoshiharu; Matsuzaki, Yuji; Yamataka, Kazunobu; Ikeda, Satoru; Shinkai, Hisashi
Journal of Medicinal Chemistry, 2009 , vol. 52, # 15 p. 4869 - 4882
反应条件
potassium tert-butylate; water in diethyl ether T=25°C; 2 h;
参考文献
Rausis, Thierry; Schlosser, Manfred
European Journal of Organic Chemistry, 2002 , # 19 p. 3351 - 3358
反应条件
1: 1,3-difluoro-2-iodobenzene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexane T=-75°C; 2 h; 2: carbon dioxide in tetrahydrofuran; hexane
参考文献
Synthesis, , # 4 art. no. T11504SS, p. 617 - 621
反应条件
1.1: 78 percent / sec-BuLi / tetrahydrofuran; cyclohexane / -75 °C 2.1: t-BuOK; lithium 2,2,6,6-tetramethylpiperidine; I2 / tetrahydrofuran; hexane / -75 °C 2.2: 33 percent / BF3*Et2O / 20 h / 25 °C 3.1: 97 percent / tBuOK; H2O / diethyl ether / 2 h / 25 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 19 p. 3351 - 3358
反应条件
1: 66 percent / LDA; I2 / tetrahydrofuran; hexane / -75 °C 2: 18 percent Chromat. / LDA / tetrahydrofuran; hexane / -75 °C 3: 97 percent / tBuOK; H2O / diethyl ether / 2 h / 25 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 19 p. 3351 - 3358
反应条件
1.1: LDA / tetrahydrofuran; hexane / -75 °C 1.2: 49 percent / BF3*Et2O / 20 h / 25 °C 2.1: 97 percent / tBuOK; H2O / diethyl ether / 2 h / 25 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 19 p. 3351 - 3358
反应条件
1: 18 percent Chromat. / LDA / tetrahydrofuran; hexane / -75 °C 2: 97 percent / tBuOK; H2O / diethyl ether / 2 h / 25 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 19 p. 3351 - 3358
