1: With hydrogen bromide; bromine in water T=0°C; 0.166667 h; 2: With sodium nitrite in water T=-10 - 20°C; 3: With sodium hydroxide in water T=0°C; pH=> 10;
参考文献
SMITHKLINE BEECHAM CORPORATION; VITAE PHARMACEUTICALS, INC.
Patent: WO2008/124582 A1, 2008 ;
Location in patent: Page/Page column 92-93 ;
WO 2008/124582 A1
1: triethylamine; [Pt(triphenylphosphine)2Cl2]; copper(l) iodide / 40 °C / |Inert atmosphere 2: potassium hydroxide / methanol; dichloromethane / 2 h / 20 °C View Scheme
参考文献
JANSSEN PHARMACEUTICA NV; Gijsen, Henricus Jacobus Maria; De Cleyn, Michel Anna Jozef; Surkyn, Michel; Verbist, Bie Maria Pieter
Patent: US2013/324529 A1, 2013 ;
