1: With n-butyllithium in hexane T=-78°C; 1 h; 2: With iodine in tetrahydrofuran; hexane T=-78 - 20°C; 1 h;

sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in ethanol; water; toluene T=105°C; 1 h;

1.1: 50 percent / Pd(PPh3)4; aq. K2CO3 / toluene; ethanol / 18 h / Heating 2.1: 2,2,6,6-tetramethylpiperidine; n-BuLi / tetrahydrofuran / 1.5 h / -50 °C 2.2: 66 percent / D2O / tetrahydrofuran 3.1: 96 percent / Pd(PPh3)4; K2CO3 / dioxane / 18 h / Heating View Scheme