1-(3-溴丙基)胸腺嘧啶合成路线 （共 12 条）
反应条件
1: HMDS / 20 °C 2: 62 percent View Scheme
参考文献
Kim; Gokel
Journal of the Chemical Society - Series Chemical Communications, 1987 , # 22 p. 1686-1688
参考文献
De Wall, Stephen L.; Barbour, Leonard J.; Schall, Otto F.; Gokel, George W.
Journal of Chemical Crystallography, 2000 , vol. 30, # 4 p. 227 - 231
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=20°C; Alkylation; 40 h;
参考文献
Itahara, Toshio
Bulletin of the Chemical Society of Japan, 1997 , vol. 70, # 9 p. 2239 - 2247
参考文献
Fenick, David J.; Falvey, Daniel E.
Journal of Organic Chemistry, 1994 , vol. 59, # 17 p. 4791 - 4799
反应条件
hydrogen bromide in water RT, 30 min, 100 deg C; Product distribution;
参考文献
Dezor-Mazur, Maria; Koraniak, Henryk; Langer, Jerzy J.; Golankiewicz, Krzysztof
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 1209 - 1212
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 15 h;
参考文献
Itahara, Toshio
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 3 p. 309 - 317
反应条件
tri-n-butyl-tin hydride in ethanol Irradiationvarious n-Bu3SnH concentration; Product distributionRate constant;
参考文献
Fenick, David J.; Falvey, Daniel E.
Journal of Organic Chemistry, 1994 , vol. 59, # 17 p. 4791 - 4799
反应条件
1: 60 percent / 0.1 M aq. NaOH / 20 h / Ambient temperature
2: 1 M aq. NaOH / 0.33 h / 80 °C
View Scheme
参考文献
Dezor-Mazur, Maria; Koraniak, Henryk; Langer, Jerzy J.; Golankiewicz, Krzysztof
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 1209 - 1212
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=70°C; Yield given;
参考文献
Decout; Lhomme
Tetrahedron Letters, 1981 , vol. 22, # 13 p. 1247 - 1250
反应条件
potassium carbonate in ethanol; water
168 h; Ambient temperature;
参考文献
Nagai, Katsuyuki; Kondo, Hirosato; Tsuruzoe, Nobutomo; Hayakawa, Kenji; Kanematsu, Ken
Heterocycles, 1982 , vol. 19, # 1 p. 53 - 56
