2-溴-5-甲氧基苯甲酸合成路线 （共 95 条）
反应条件
1: With sodium hydride; copper(I) bromide T=80°C; 0.5 h; 2: With sodium hydroxide; water T=20°C; 18 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/67444 A1, 2006 ;
Location in patent: Page/Page column 64-65 ;
WO 2006/067444 A1
反应条件
1: sodium carbonate / tris(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxy-ethane; H2O / 85 °C 2: sodium hydroxide / ethanol / 78 °C View Scheme
参考文献
Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4601 - 4611
反应条件
1: SOCl2 / 1 h / Heating 2: H2O / 1 h View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
反应条件
Multistep reaction. Title compound not separated from byproducts;
参考文献
Cipollina, Joseph A.; Ruediger, Edward H.; New, James S.; Wire, Mary E.; Shepherd, Timothy A.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3316 - 3328
反应条件
1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 50 °C 2: tetrahydrofuran / 16 h / 20 °C View Scheme
参考文献
Woodward, David F.; Martos, Jose L.; Carling, William R.; Poloso, Neil J.; Wang, Jenny W.
Patent: US2012/270915 A1, 2012 ;
US 20120270915 A1
反应条件
aluminium trichloride; chlorobenzene T=170°C;
参考文献
American Cyanamid Co.
Patent: US5519133 A1, 1996 ;
反应条件
1: 98 percent / SOCl2 / 18 h / Heating View Scheme
参考文献
Thome, Isabelle; Besson, Claire; Kleine, Tillmann; Bolm, Carsten
Angewandte Chemie - International Edition, 2013 , vol. 52, # 29 p. 7509 - 7513
Angew. Chem., 2013 , vol. 125, # 29 p. 7657 - 7661,5
反应条件
thionyl chloride 18 h; Heating;
参考文献
Hellwinkel, Dieter; Bohnet, Siegbert
Chemische Berichte, 1987 , vol. 120, p. 1151 - 1174
反应条件
N,N-dimethyl-formamide in dichloromethane
参考文献
Wagenen, Bradford Van; Stormann, Thomas M.; Moe, Scott T.; Sheehan, Susan M.; McLeod, Donald A.; Smith, Daryl L.; Isaac, Methvin Benjamin; Slassi, Abdelmalik
Patent: US2003/55085 A1, 2003 ;
US 20030055085 A1
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran; diethyl ether 1 h; Heating; 2: With pyridinium chlorochromate in dichloromethane 1 h; Heating; Further stages.;
参考文献
Spring, David R.; Krishnan, Shyam; Blackwell, Helen E.; Schreiber, Stuart L.
Journal of the American Chemical Society, 2002 , vol. 124, # 7 p. 1354 - 1363
