2-溴-5-甲氧基苯甲酸合成路线 （共 95 条）
反应条件
1: thionyl chloride
2: CH2Cl2
3: thionyl chloride / toluene
4: NaOH / methanol / Heating
View Scheme
参考文献
Tang, Xiubo; Zhang, Dongheng; Jie, Suyun; Sun, Wen-Hua; Chen, Jiutong
Journal of Organometallic Chemistry, 2005 , vol. 690, # 17 p. 3918 - 3928
反应条件
3-methyl-1-butanol; potassium ethanolate; copper(l) chloride
weiteres Reagens: Kupfer;
参考文献
Singh; Singh
Journal of the Indian Chemical Society, 1946 , vol. 23, p. 226
Full Text Show Details
Dauben
Journal of the American Chemical Society, 1948 , vol. 70, p. 2420,2422
反应条件
3-methyl-1-butanol; copper; potassium carbonate
参考文献
Friedheim; Bergmann
Patent: US2389147 , 1943 ;
反应条件
copper; potassium carbonate in pentan-1-ol
3 h; Heating;
参考文献
Orda-Zgadzaj, Marzena; Abraham, Werner
Synthesis, 2007 , # 21 art. no. T09407SS, p. 3345 - 3356
反应条件
sulfuric acid
30 h; Heating;
参考文献
Matos, Marie-Christine; Murphy, Paul V.
Journal of Organic Chemistry, 2007 , vol. 72, # 5 p. 1803 - 1806
反应条件
sulfuric acid in ethanol
20 h; RefluxLarge scale;
参考文献
Watson, Timothy J.; Ayers, Timothy A.; Shah, Nik; Wenstrup, David; Webster, Mark; Freund, David; Horgan, Stephen; Carey, James P.
Organic Process Research and Development, 2003 , vol. 7, # 4 p. 521 - 532
反应条件
1: 2-bromo-5-methoxy benzoic acid With thionyl chloride
T=80°C; 2 h; Inert atmosphere;
2: benzene With AlCl3, aluminium chloride
T=80°C; Friedel-Crafts Acylation; 1 h; Inert atmosphere;
参考文献
Nagahora, Noriyoshi; Wasano, Tatsuya; Nozaki, Kazuhiro; Ogawa, Tamaki; Nishijima, Shuhei; Motomatsu, Daiki; Shioji, Kosei; Okuma, Kentaro
European Journal of Organic Chemistry, 2014 , vol. 2014, # 7 p. 1423 - 1430
反应条件
1: thionyl chloride / CHCl3 / 3 h / Heating
2: 2.3 g / aluminum chloride / 6 h / Heating
View Scheme
参考文献
Tian, Yulin; Qi, Jianguo; Sun, Chenbin; Yin, Dali; Wang, Xiaojian; Xiao, Qiong
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 42 p. 7262 - 7266
反应条件
1: 99 percent / H2SO4 / 3 h / Heating
2: 57 percent / Pd(PPh3)4 / benzene / 20 h / 120 °C
3: 79 percent / NaOH / H2O; ethanol / 1 h / Heating
View Scheme
参考文献
Ozaki, Shigeko; Adachi, Masashi; Sekiya, Sayaka; Kamikawa, Rie
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4586 - 4589
反应条件
1: sodium hydroxide / water
2: sodium acetate / N,N-dimethyl-formamide / 120 °C
3: water; sodium sulfite / methanol / 20 °C
View Scheme
参考文献
Arai, Shigeru; Nakajima, Masaya; Nishida, Atsushi
Angewandte Chemie - International Edition, 2014 , vol. 53, # 22 p. 5569 - 5572
Angew. Chem., 2014 , vol. 126, # 22 p. 5675 - 5678,4
