4-氯-6-甲氧基喹啉-3-甲酸乙酯合成路线 （共 11 条）
反应条件
1: With trichlorophosphate T=25 - 100°C; 5 h; Heating / reflux; 2: With sodium hydroxide in dichloromethane; water T=25 - 30°C; pH=7.5 - 8; 1.5 h;
参考文献
Aventis Pharma S.A.
Patent: US2005/182259 A1, 2005 ;
Location in patent: Page/Page column 5 ;
反应条件
in trichlorophosphate
参考文献
SENOMYX, INC.; TACHDJIAN, Catherine; TANG, Xiao Qing; KARANEWSKY, Donald S.; SERVANT, Guy; LI, Xiaodong; ZHANG, Feng; CHEN, Qing; ZHANG, Hong; DAVIS, Timothy; DARMOHUSODO, Vincent; WONG, Melissa; SELCHAU, Victor
Patent: WO2013/25560 A1, 2013 ;
Location in patent: Page/Page column 52; 53 ;
反应条件
1: 2 h / 110 - 115 °C 2: various solvent(s) / 0.5 h / 250 °C 3: 54 percent / POCl3 / 5 h / Heating View Scheme
参考文献
Farmaco, , vol. 53, # 8-9 p. 579 - 585
反应条件
thionyl chloride 17 h; Reflux;
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1448 - 1452
反应条件
1: various solvent(s) / Heating 2: POCl3 / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 11 p. 1669 - 1673
反应条件
1.1: 1 h / 140 °C / Inert atmosphere 1.2: 2 h / Reflux; Inert atmosphere 2.1: trichlorophosphate / 0.33 h / 110 °C / Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 7 p. 3578 - 3582
反应条件
sodium tetrahydroborate; palladium dichloride in methanol T=20°C; 1 h;
参考文献
Hanna-Elias, Amir; Manallack, David T.; Berque-Bestel, Isabelle; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.
Australian Journal of Chemistry, 2009 , vol. 62, # 2 p. 150 - 156
反应条件
hydrogen; triethylamine; palladium on activated carbon in ethanol; water T=33°C; P=375.038 - 600.06 Torr; 48 h;
参考文献
Aventis Pharma S.A.
Patent: US2005/182259 A1, 2005 ;
Location in patent: Page/Page column 4-5 ;
反应条件
ammonia in isopropyl alcohol
参考文献
SENOMYX, INC.; TACHDJIAN, Catherine; TANG, Xiao Qing; KARANEWSKY, Donald S.; SERVANT, Guy; LI, Xiaodong; ZHANG, Feng; CHEN, Qing; ZHANG, Hong; DAVIS, Timothy; DARMOHUSODO, Vincent; WONG, Melissa; SELCHAU, Victor
Patent: WO2013/25560 A1, 2013 ;
Location in patent: Page/Page column 52 ;
