1: K2CO3, 18-crown-6-ether / dimethylformamide / 36 h / 40 °C 2: 5N NaOH / ethanol / 0.83 h / Heating 3: TFA / CH2Cl2 / 3 h / Ambient temperature 4: 98 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 5: 97 percent / p-toluenesulfonyl chloride, pyridine / 24 h / Heating 6: 55 percent / isoamyl nitrite, CH2I2 / 0.33 h / 100 °C 7: (PhCN)2PdCl2 / acetonitrile / 14 h / 100 °C 8: NH3 / methanol 9: 70 percent / NH3 / methanol / 12 h / 120 °C 10: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: K2CO3, 18-crown-6-ether / dimethylformamide / 36 h / 40 °C 2: 5N NaOH / ethanol / 0.83 h / Heating 3: TFA / CH2Cl2 / 3 h / Ambient temperature View Scheme