1-溴-4-丙-2-烯基苯合成路线 （共 25 条）
反应条件
1: With borane in tetrahydrofuran T=0°C; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=0 - 20°C; 3 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2006/61791 A2, 2006 ;
Location in patent: Page/Page column 15 ;
WO 2006/061791 A2
反应条件
hydrogen; platinum(IV) oxide in ethanol
参考文献
Franks, Stephen; Hartley, Frank R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2233 - 2237
反应条件
1.1: iron (III) acetylacetonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; 2,4,6-trimethylphenyl iodide / tetrahydrofuran / 0.5 h / 20 °C / |Inert atmosphere 1.2: 0.5 h / 0 °C / |Inert atmosphere 2.1: iron (III) acetylacetonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; 2,4,6-trimethylphenyl iodide / tetrahydrofuran / 0.5 h / 20 °C / |Inert atmosphere 2.2: 0.5 h / 0 °C / |Inert atmosphere View Scheme
参考文献
Sekine, Masaki; Ilies, Laurean; Nakamura, Eiichi
Organic Letters, 2013 , vol. 15, # 3 p. 714 - 717
反应条件
1.1: magnesium / diethyl ether / 1 h / Heating
1.2: 41 percent / diethyl ether / 20 °C
2.1: 92 percent / PCC / CH2Cl2 / 7 h / 20 °C
View Scheme
参考文献
Gan, Yonghong; Wang, Pingzhen; Spencer, Thomas A.
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9487 - 9490
反应条件
osmium(VIII) oxide; 4-methylmorpholine N-oxide in water; acetone
T=20°C; 2 h;
参考文献
Actelion Pharmaceuticals Ltd.
Patent: EP1863475 B1, 2011 ;
