反应条件
1: 2,4(3H,5H)-Thiazoledione With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=20 - 60°C; 1 h; Inert atmosphere;
2: 1,4-dibromo-butane in N,N-dimethyl-formamide; mineral oil
T=110°C; 3 h; Inert atmosphere;
参考文献
Marco, Isabel; Valhondo, Margarita; Martin-Fontecha, Mar; Vazquez-Villa, Henar; Del Rio, Joaquin; Planas, Anna; Sagredo, Onintza; Ramos, Jose A.; Torrecillas, Ivan R.; Pardo, Leonardo; Frechilla, Diana; Benhamu, Bellinda; Lopez-Rodriguez, Maria L.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 23 p. 7986 - 7999