5-硝基-1,2-苯并异噻唑-3(2H)-酮 1,1-二氧化物合成路线 （共 7 条）
反应条件
hydrogen; palladium on activated charcoal
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/129100 A1, 2006 ;
Location in patent: Page/Page column 36 ;
WO 2006/129100 A1
反应条件
potassium permanganate; hydroxide
参考文献
Warren,A.; Hamor,G.H.
Journal of Pharmaceutical Sciences, 1961 , vol. 50, p. 625 - 626
反应条件
1: Br2 / CCl4 / 6 h / Heating
2: aq. H2O2, AcOH / 1.5 h / 100 °C
View Scheme
参考文献
Ponci,R. et al.
Farmaco, Edizione Scientifica, 1963 , vol. 18, p. 732 - 749
反应条件
hydrogenchloride; ammonium hydroxide; sulfur dioxide; copper dichloride; sodium nitrite
1) Acetic acid, room temperature, 3 h, 2) 18 h.; Yield given. Multistep reaction;
参考文献
Saari; Schwering
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 4 p. 1253 - 1255
反应条件
1: K2CO3
2: 1.) NaNO2, 2.) CuCl2, SO2, aq. NH3
View Scheme
参考文献
Nerenberg, Jennie B.; Erb, Jill M.; Thompson, Wayne J.; Lee, Hee-Yoon; Guare, James P.; Munson, Peter M.; Bergman, Jeffrey M.; Huff, Joel R.; Broten, Theodore P.; Chang, Raymond S. L.; Chen, Tsing B.; O'Malley, Stacey; Schorn, Terry W.; Scott, Ann L.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 18 p. 2467 - 2472
反应条件
1.1: sodium nitrite; hydrogenchloride / 0.5 h / 0 °C
1.2: 0.5 h / 20 °C
2.1: (NH4)2CO3 / 1 h / |Heating
3.1: chromium(VI) oxide; sulfuric acid / 72 h / 20 °C
View Scheme
参考文献
Elsayed, Mohamed S.A.; El-Araby, Moustafa E.; Serya, Rabah A.T.; El-Khatib, Ahmed H.; Linscheid, Michael W.; Abouzid, Khaled A.M.
European Journal of Medicinal Chemistry, 2013 , vol. 61, p. 122 - 131
反应条件
1: (NH4)2CO3 / 1 h / |Heating
2: chromium(VI) oxide; sulfuric acid / 72 h / 20 °C
View Scheme
参考文献
Elsayed, Mohamed S.A.; El-Araby, Moustafa E.; Serya, Rabah A.T.; El-Khatib, Ahmed H.; Linscheid, Michael W.; Abouzid, Khaled A.M.
European Journal of Medicinal Chemistry, 2013 , vol. 61, p. 122 - 131
