4-氰基-3-氟苄基氨基甲酸叔丁酯合成路线 （共 6 条）
反应条件
in dichloromethane T=20°C; 1 h;
参考文献
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; STRONGIN, Alex; PELLECCHIA, Maurizio; BARILE, Elisa
Patent: WO2013/138665 A1, 2013 ;
Location in patent: Paragraph 00092 ;
反应条件
1: 94 percent / dimethylformamide / 5 h / Heating 2: 54 percent / NBS; AIBN / CCl4 / 4.5 h / Heating 3: 91 percent / Cs2CO3 / dimethylformamide / 0.5 h / 20 °C 4: NH2NH2 / butan-1-ol / 0.08 h / Heating 5: CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Cui, Jingrong Jean; Araldi, Gian-Luca; Reiner, John E.; Reddy, Komandla Malla; Kemp, Scott J.; Ho, Jonathan Z.; Siev, Daniel V.; Mamedova, Lala; Gibson, Tony S.; Gaudette, John A.; Minami, Nathaniel K.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2925 - 2930
反应条件
1: 54 percent / NBS; AIBN / CCl4 / 4.5 h / Heating 2: 91 percent / Cs2CO3 / dimethylformamide / 0.5 h / 20 °C 3: NH2NH2 / butan-1-ol / 0.08 h / Heating 4: CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Cui, Jingrong Jean; Araldi, Gian-Luca; Reiner, John E.; Reddy, Komandla Malla; Kemp, Scott J.; Ho, Jonathan Z.; Siev, Daniel V.; Mamedova, Lala; Gibson, Tony S.; Gaudette, John A.; Minami, Nathaniel K.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2925 - 2930
反应条件
1: 91 percent / Cs2CO3 / dimethylformamide / 0.5 h / 20 °C 2: NH2NH2 / butan-1-ol / 0.08 h / Heating 3: CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Cui, Jingrong Jean; Araldi, Gian-Luca; Reiner, John E.; Reddy, Komandla Malla; Kemp, Scott J.; Ho, Jonathan Z.; Siev, Daniel V.; Mamedova, Lala; Gibson, Tony S.; Gaudette, John A.; Minami, Nathaniel K.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2925 - 2930
反应条件
1: NH2NH2 / butan-1-ol / 0.08 h / Heating 2: CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Cui, Jingrong Jean; Araldi, Gian-Luca; Reiner, John E.; Reddy, Komandla Malla; Kemp, Scott J.; Ho, Jonathan Z.; Siev, Daniel V.; Mamedova, Lala; Gibson, Tony S.; Gaudette, John A.; Minami, Nathaniel K.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2925 - 2930
反应条件
1: Me2CNOH; t-BuOK / tetrahydrofuran
2: aq. HCl / ethanol / Heating
View Scheme
参考文献
Trujillo, John I.; Huang, Horng-Chih; Neumann, William L.; Mahoney, Matthew W.; Long, Scott; Huang, Wei; Garland, Danny J.; Kusturin, Carrie; Abbas, Zaheer; South, Michael S.; Reitz, David B.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4568 - 4574
