1-苯基-1,2,3,4-四氢异喹啉合成路线 （共 79 条）
反应条件
methanol; sodium tetrahydroborate in water T=20 - 34°C; 5.41667 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/128028 A2, 2008 ;
Location in patent: Page/Page column 28 ;
反应条件
potassium hydroxide; water in dimethyl sulfoxide T=160°C; 15 h;
参考文献
WO2008/11462 A2, ;
Page/Page column 21 ;
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene T=85°C; 1 h;
参考文献
Journal of the American Chemical Society, , vol. 125, # 1 p. 163 - 168
反应条件
hydrogen; Pd/C oxidized form in methanol T=20°C; 16 h; atmospheric pressure;
参考文献
Ludwig, Matthias; Hoesl, Cornelia E.; Hoefner, Georg; Wanner, Klaus T.
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 8 p. 1003 - 1010
反应条件
1: With hydrogenchloride; phosphoric acid; water T=95 - 100°C; 32 h; 2: With sodium hydroxide in water T=20°C; pH=9 - 10;
参考文献
WO2011/48607 A1, ;
Page/Page column 14; 15 ;
反应条件
di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (R)-3,5-diMe-Synphos; hydrogen in 1,4-dioxane T=40°C; P=22502.3 Torr; 18 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Organic Letters, , vol. 14, # 13 p. 3308 - 3311
反应条件
di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (R)-3,5-diMe-Synphos; hydrogen; potassium carbonate in 1,4-dioxane T=40°C; P=22502.3 Torr; 18 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Berhal, Farouk; Wu, Zi; Zhang, Zhaoguo; Ayad, Tahar; Ratovelomanana-Vidal, Virginie
Organic Letters, 2012 , vol. 14, # 13 p. 3308 - 3311
反应条件
sodium tetrahydroborate in methanol T=20°C; 3 h;
参考文献
Bolchi, Cristiano; Pallavicini, Marco; Fumagalli, Laura; Straniero, Valentina; Valoti, Ermanno
Organic Process Research and Development, 2013 , vol. 17, # 3 p. 432 - 437
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-100 - -95°C; 0.25 h;
参考文献
Bradsher, Charles K.; Hunt, David A.
Journal of Organic Chemistry, 1981 , vol. 46, # 2 p. 327 - 330
反应条件
1: POCl3 2: NaBH4 / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 27 p. 4585 - 4589
