1-苯基-1,2,3,4-四氢异喹啉合成路线 （共 79 条）
反应条件
trifluorormethanesulfonic acid T=120°C; 15 h;
参考文献
Yokoyama, Akihiro; Ohwada, Tomohiko; Shudo, Koichi
Journal of Organic Chemistry, 1999 , vol. 64, # 2 p. 611 - 617
反应条件
1: 0.928 g / CH2Cl2; tetrahydrofuran / 4 h / cooling 2: 91 percent / hydrogen / Pd/C oxidized form / methanol / 16 h / 20 °C / atmospheric pressure View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 41, # 8 p. 1003 - 1010
反应条件
1: 89 percent / NEt3 / CH2Cl2 / 17 h / 20 °C 2: Ph3C(1+)*BF4(1-) / CH2Cl2 / 16 h / 20 °C 3: 0.928 g / CH2Cl2; tetrahydrofuran / 4 h / cooling 4: 91 percent / hydrogen / Pd/C oxidized form / methanol / 16 h / 20 °C / atmospheric pressure View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 41, # 8 p. 1003 - 1010
反应条件
1: Ph3C(1+)*BF4(1-) / CH2Cl2 / 16 h / 20 °C 2: 0.928 g / CH2Cl2; tetrahydrofuran / 4 h / cooling 3: 91 percent / hydrogen / Pd/C oxidized form / methanol / 16 h / 20 °C / atmospheric pressure View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 41, # 8 p. 1003 - 1010
反应条件
1: 1.) NaHCO3, tert-butyl hypochlorite, 2.) KO2, 18-crown-6 ether / 1.) ether, 10 deg C, 2.) ether, 4.5 h View Scheme
参考文献
Heterocycles, , vol. 19, # 4 p. 653 - 656
反应条件
1: 83 percent / dimethylformamide / 15 h / 90 °C 2: 1.) hydrazine hydrate 2.)concentrated HCl / 1.) methanol, reflux, 1h; 2.) reflux, 1.5 h 3: 66 percent / benzene / Heating 4: 42 percent / butyllithium / tetrahydrofuran; hexane / 0.25 h / -100 - -95 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 2 p. 327 - 330
反应条件
1: LiAlH4 / diethyl ether / 5 h / 0 - 5 °C 2: 66 percent / benzene / Heating 3: 42 percent / butyllithium / tetrahydrofuran; hexane / 0.25 h / -100 - -95 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 2 p. 327 - 330
反应条件
1: 66 percent / benzene / Heating 2: 42 percent / butyllithium / tetrahydrofuran; hexane / 0.25 h / -100 - -95 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 2 p. 327 - 330
反应条件
1: 1.) hydrazine hydrate 2.)concentrated HCl / 1.) methanol, reflux, 1h; 2.) reflux, 1.5 h 2: 66 percent / benzene / Heating 3: 42 percent / butyllithium / tetrahydrofuran; hexane / 0.25 h / -100 - -95 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 2 p. 327 - 330
反应条件
diborane in tetrahydrofuran 24 h; Ambient temperature;
参考文献
Zara-Kaczian, Erzsebet; Deak, Gyula; Toth, Gabor
Journal of Chemical Research, Miniprint, 1984 , # 9 p. 2533 - 2555
