1-苯基-1,2,3,4-四氢异喹啉合成路线 （共 79 条）
反应条件
sodium hydrogen telluride in ethanol 6 h; Heating;
参考文献
Barton, Derek H.R.; Fekih, Abdelwaheb; Lusinchi, Xavier
Tetrahedron Letters, 1985 , vol. 26, # 38 p. 4603 - 4606
反应条件
1: (isoPrO)4Ti / 3 h / 80 °C 2: NaBH4 / methanol / 1 h / Ambient temperature 3: 98 percent / Ac2O / 1 h / 70 °C 4: 97 percent / NaIO4 / H2O; methanol / Ambient temperature 5: 1.) TFAA; 2.) BF3*Et2O / 1.) benzene, RT, 1 h; 2.) benzene, RT, 1 h 6: 89 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 7: 92 percent / aq. NaOH / ethanol / 20 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
反应条件
1: 98 percent / Ac2O / 1 h / 70 °C 2: 97 percent / NaIO4 / H2O; methanol / Ambient temperature 3: 1.) TFAA; 2.) BF3*Et2O / 1.) benzene, RT, 1 h; 2.) benzene, RT, 1 h 4: 89 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 5: 92 percent / aq. NaOH / ethanol / 20 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
反应条件
1: 97 percent / NaIO4 / H2O; methanol / Ambient temperature 2: 1.) TFAA; 2.) BF3*Et2O / 1.) benzene, RT, 1 h; 2.) benzene, RT, 1 h 3: 89 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 4: 92 percent / aq. NaOH / ethanol / 20 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
反应条件
1: 1.) TFAA; 2.) BF3*Et2O / 1.) benzene, RT, 1 h; 2.) benzene, RT, 1 h 2: 89 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 3: 92 percent / aq. NaOH / ethanol / 20 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
反应条件
2: 79 percent / 2.06 M HCl / methanol / 27 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 39, # 12 p. 1963 - 1974
反应条件
1: NaAlH2(OCH2CH2OCH3)2 / tetrahydrofuran / 7 h / 0 - 5 °C / further solvent, varying concentration, temperature and reaction time 2: 91 percent / Et3N / diethyl ether / 6 h / Heating 4: 79 percent / 2.06 M HCl / methanol / 27 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 39, # 12 p. 1963 - 1974
反应条件
1: potassium hydroxide / methanol / 1 h / 20 °C 2: sodium tetrahydroborate / methanol / 3 h / 20 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 17, # 3 p. 432 - 437
反应条件
sodium tetrahydroborate; nickel dichloride in methanol Ambient temperature; Yield given;
参考文献
Journal of Chemical Research, Miniprint, , # 2 p. 527 - 553
反应条件
1: 94 percent / aq. KOH / ethanol; H2O / 1 h / -5 - 0 °C 2: 42 percent / LiAlH4 / tetrahydrofuran / 20 h / Ambient temperature 3: toluene / 2 h / Heating 4: 75 percent / TFA / toluene / 5 h / Heating 5: NiCl2*6H2O, NaBH4 / methanol / Ambient temperature View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 2 p. 527 - 553
