1-苯基-1,2,3,4-四氢异喹啉合成路线 (共 79 条)
参考文献
Journal of the Chemical Society, , p. 2587
反应条件
potassium carbonate in dichloromethane T=20°C;
参考文献
Naito, Ryo; Yonetoku, Yasuhiro; Okamoto, Yoshinori; Toyoshima, Akira; Ikeda, Ken; Takeuchi, Makoto
Journal of Medicinal Chemistry, 2005 , vol. 48, # 21 p. 6597 - 6606
反应条件
1: (2S,3S)-2,3-dihydroxybutanedioic acid / water / 1.5 h / 65 - 95 °C / Resolution of racemate 2: acetone / 5 °C / Reflux View Scheme
参考文献
CADILA HEALTHCARE LIMITED; KOTHARI, Himanshu M.; DAVE, Mayank Ghanshyambhai; PANDEY, Bipin
Patent: WO2011/48607 A1, 2011 ;
反应条件
(2S,3S)-2,3-dihydroxybutanedioic acid Resolution of racemate;
参考文献
Organic Process Research and Development, , vol. 17, # 3 p. 432 - 437
反应条件
2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=23°C; 18 h; Inert atmosphereResolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Binanzer, Michael; Hsieh, Sheng-Ying; Bode, Jeffrey W.
Journal of the American Chemical Society, 2011 , vol. 133, # 49 p. 19698 - 19701
反应条件
potassium hydroxide in water; dimethyl sulfoxide 11.8333 h; Heating / reflux; Purification / work up;
参考文献
Niphade, Navnath C.; Jagtap, Kunal M.; Mali, Anil C.; Solanki, Pavankumar V.; Jachak, Madhukar N.; Mathad, Vijayavitthal T.
Monatshefte fur Chemie, 2011 , vol. 142, # 11 p. 1181 - 1186
反应条件
potassium carbonate in dichloromethane T=20°C;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2006/35280 A1, 2006 ;
Location in patent: Page/Page column 21 ;
WO 2006/035280 A1
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US6017927 A1, 2000 ;
反应条件
in water; ethyl acetate T=25 - 60°C; 1.5 h; Product distribution / selectivity;
参考文献
Perlman, Nurit; Nidam, Tamar
Patent: US2008/91023 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
in toluene T=10 - 15°C; TemperatureTimeSolvent;
参考文献
KYUNG DONG PHARM. CO., LTD.; LEE, Byoung Suk; SHIN, Sang Hoon; LEE, Ki Young
Patent: WO2013/147458 A1, 2013 ;
Location in patent: Paragraph 129-131 ;