1-苯基-1,2,3,4-四氢异喹啉合成路线 （共 79 条）
反应条件
hydrogenchloride; borane-ammonia complex in aq. phosphate buffer T=37°C; pH=7.8;
参考文献
Ghislieri, Diego; Green, Anthony P.; Pontini, Marta; Willies, Simon C.; Rowles, Ian; Frank, Annika; Grogan, Gideon; Turner, Nicholas J.
Journal of the American Chemical Society, 2013 , vol. 135, # 29 p. 10863 - 10869
反应条件
(2S,3S)-2,3-dihydroxybutanedioic acid in water T=65 - 95°C; 1.5 h; Resolution of racemate; Purification / work up;
参考文献
WO2011/48607 A1, ;
Page/Page column 15 ;
反应条件
hydrogenchloride; borane-ammonia complex in aq. phosphate buffer T=37°C; pH=7.8;
参考文献
Journal of the American Chemical Society, , vol. 135, # 29 p. 10863 - 10869
反应条件
(2S,3S)-2,3-dihydroxybutanedioic acid Resolution of racemate;
参考文献
Organic Process Research and Development, , vol. 17, # 3 p. 432 - 437
反应条件
2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=23°C; 18 h; Inert atmosphereResolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 133, # 49 p. 19698 - 19701
反应条件
in ethanol T=75°C; 24 h;
参考文献
Vlaeminck, F.; Cock, E. De; Tourwe, D.; Binst, G. Van
Heterocycles, 1981 , vol. 15, # 2 p. 1213 - 1218
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane
0.25 h; Ambient temperature;
参考文献
Gray, Nancy M.; Cheng, Brian K.; Mick, Stephen J.; Lair, Cecelia M.; Contreras, Patricia C.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1242 - 1248
反应条件
pyridine
18 h; Ambient temperature;
参考文献
Brooks, Donald J.; Dowell, David S.; Minter, David E.; Villarreal, Mark C.
Journal of Organic Chemistry, 1984 , vol. 49, p. 130 - 133
反应条件
1: 82.4 percent / benzene / 5 h / Heating
2: 48 percent / 17percent ethanolic hydrogen chloride / CHCl3 / 8 h / Heating
View Scheme
参考文献
Zara-Kaczian; Deak Gy.
Acta Chimica Hungarica, 1984 , vol. 116, # 1 p. 89 - 94
