(2,5-二甲基-苯基)-(4-甲氧基-苯基)-甲酮合成路线 （共 10 条）
反应条件
copper ferrite in neat (no solvent) T=80°C; Friedel-Crafts Acylation; 18 h;
参考文献
Parella, Ramarao; Naveen; Kumar, Amit; Babu, Srinivasarao Arulananda
Tetrahedron Letters, 2013 , vol. 54, # 13 p. 1738 - 1742
反应条件
aluminium trichloride in dichloromethane T=20°C; Acylation; Friedel-Crafts reaction; 1 h;
参考文献
Taber, Douglass F.; Sethuraman, Maya R.
Journal of Organic Chemistry, 2000 , vol. 65, # 1 p. 254 - 255
反应条件
1: 4-methoxybenzoic acid t-butyl ester With indium tribromide; dimethylmono-chlorosilane in 1,2-dichloro-ethane T=20°C; 2 h; Inert atmosphere; 2: para-xylene in 1,2-dichloro-ethane T=100°C; Friedel Crafts acylation; 10 h; regioselective reaction;
参考文献
Nishimoto, Yoshihiro; Babu, Srinivasarao Arulananda; Yasuda, Makoto; Baba, Akio
Journal of Organic Chemistry, 2008 , vol. 73, # 23 p. 9465 - 9468
反应条件
1: AlCl3 / CH2Cl2 / 0.5 h / 10 °C 2: 1.78 g / AlCl3 / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Taber, Douglass F.; Sethuraman, Maya R.
Journal of Organic Chemistry, 2000 , vol. 65, # 1 p. 254 - 255
参考文献
Effenberger, Franz; Koenig, Gerd; Klenk, Herbert
Chemische Berichte, 1981 , vol. 114, # 3 p. 926 - 936
反应条件
diphosphoric acid tetrachloride 1) CHCl3, 70 deg C, 7 h, 2) CHCl3, 70 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Effenberger, Franz; Koenig, Gerd; Klenk, Herbert
Chemische Berichte, 1981 , vol. 114, # 3 p. 926 - 936
反应条件
bromine; Tl(Oac)3 in tetrachloromethane
0.5 h; Heating;
参考文献
Popplestone Andrew; Sainsbury, Malcolm
Tetrahedron, 1983 , vol. 39, # 24 p. 4103 - 4108
反应条件
1: 61 percent / Br2, thallium(III)acetate sesquihydrate / CCl4 / 0.5 h / Heating
2: 65 percent / KOH, hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / 2 h / Heating
View Scheme
参考文献
Popplestone Andrew; Sainsbury, Malcolm
Tetrahedron, 1983 , vol. 39, # 24 p. 4103 - 4108
反应条件
1: 61 percent / Br2, thallium(III)acetate sesquihydrate / CCl4 / 0.5 h / Heating
2: 65 percent / KOH, hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / 2 h / Heating
3: 85 percent / K2CO3 / acetone / 2.5 h / Heating
View Scheme
参考文献
Popplestone Andrew; Sainsbury, Malcolm
Tetrahedron, 1983 , vol. 39, # 24 p. 4103 - 4108
反应条件
pyridine; potassium permanganate in water
5 h; Heating;
参考文献
Hibbs, Michael R.; Vargas, Marian; Holtzclaw, Jeremy; Rich, Wendy; Collard, David M.; Schiraldi, David A.
Macromolecules, 2003 , vol. 36, # 20 p. 7543 - 7551
