1-甲基-4-氯吡唑并[3,4-d]嘧啶合成路线 (共 9 条)
反应条件
1: 4,6-dichloro-pyrimidine-5-carboxaldehyde With N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=0°C; 0.166667 h; Inert atmosphere; 2: methylhydrazine in tetrahydrofuran T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
trichlorophosphate in Petroleum ether
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4124764 A1, 1978 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide T=0°C; 3 h;
参考文献
US2007/281949 A1, ;
Page/Page column 37 ;
反应条件
1: 4,6-dichloro-pyrimidine-5-carboxaldehyde With triethylamine in tetrahydrofuran T=0°C; 0.166667 h; Inert atmosphere; 2: monomethyl hydrazine hydrochloride in tetrahydrofuran T=20°C; 1 h; Inert atmosphere;
参考文献
Babu, Suresh; Morrill, Christie; Almstead, Neil G.; Moon, Young-Choon
Organic Letters, 2013 , vol. 15, # 8 p. 1882 - 1885
反应条件
trichlorophosphate 2 h; Heating;
参考文献
Miyashita, Akira; Suzuki, Yumiko; Ohta, Kiyono; Higashino, Takeo
Heterocycles, 1994 , vol. 39, # 1 p. 345 - 356
反应条件
ethanol; ammonia T=160°C;
参考文献
Cheng; Robins
Journal of Organic Chemistry, 1956 , vol. 21, p. 1240,1242
反应条件
palladium on activated charcoal; ammonia
Hydrogenation;
参考文献
Cheng; Robins
Journal of Organic Chemistry, 1956 , vol. 21, p. 1240,1242
参考文献
Cheng; Robins
Journal of Organic Chemistry, 1956 , vol. 21, p. 1240,1242
参考文献
Cheng; Robins
Journal of Organic Chemistry, 1956 , vol. 21, p. 1240,1242