4,5-二甲基-1H-咪唑合成路线 （共 26 条）
反应条件
sodium methylate in methanol a.) -78 deg C, 1 h, b.) -78 deg C - 23 deg C, 1 h, c.) 23 deg C, 2 h;
参考文献
Kiselyov; Strekowski
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1361 - 1364
反应条件
1: 52 percent / p-toluenesulfonic acid / Heating 2: 1.) n-BuLi / 1.) THF, hexane, -40 deg C, 30 min; 2.) room temp., overnight 3: H2O / 0.5 h / pH 4 4: 83 percent / NaBH4 / methanol View Scheme
参考文献
Skorey, K. I.; Somayaji, V.; Brown, R. S.
Journal of the American Chemical Society, 1989 , vol. 111, # 4 p. 1445 - 1452
反应条件
toluene-4-sulfonic acid
参考文献
Curtis, N.J.; Brown, R.S.
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 4038 - 4040
反应条件
T=550°C; Yield given. Yields of byproduct given;
参考文献
Busby, Reginald E.; Khan, Mohammad A.; Khan, Mohammad R.; Parrick, John; Shaw, C. J. Granville; Iqbal, Mohammad
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1427 - 1430
反应条件
in benzene
T=25°C; KineticsMechanismRate constant;
参考文献
Dadali, V. A.; Panchenko, B. V.; Litvinenko, L. M.
Journal of Organic Chemistry USSR (English Translation), 1980 , p. 1470 - 1477
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 8 p. 1725 - 1732
反应条件
T=550°C; Yield given. Yields of byproduct given;
参考文献
Busby, Reginald E.; Khan, Mohammad A.; Khan, Mohammad R.; Parrick, John; Shaw, C. J. Granville; Iqbal, Mohammad
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1427 - 1430
