2-(3,4-二甲氧基苯基)-2-甲基丙腈合成路线 （共 5 条）
反应条件
1: 2-(3,4-dimethoxyphenyl)acetonitrile With sodium hydride in tetrahydrofuran T=0°C; 0.5 h; 2: methyl iodide in tetrahydrofuran 12 h; Product distribution / selectivity;
参考文献
EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline, Eve; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin; WANG, Tie-lin
Patent: WO2010/93845 A1, 2010 ;
Location in patent: Page/Page column 133 ;
WO 2010/093845 A1
反应条件
potassium hexamethylsilazane in tetrahydrofuran T=80°C; Substitution; 4 h;
参考文献
Caron, Stephane; Vazquez, Enrique; Wojcik, Jill M.
Journal of the American Chemical Society, 2000 , vol. 122, # 4 p. 712 - 713
反应条件
1: α-methyl-3,4-dimethoxyphenylacetonitrile With sodium amide in diethyl ether; ammonia T=-78°C; 2: methyl iodide in diethyl ether; ammonia T=-78°C; 2 h; Further stages.;
参考文献
Ling; Kim; Sayre
Journal of the American Chemical Society, 2001 , vol. 123, # 39 p. 9606 - 9611
反应条件
1: sulfuric acid; water / 7 h / Reflux
2: sulfuric acid / 12 h / Reflux
View Scheme
参考文献
EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline, Eve; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin; WANG, Tie-lin
Patent: WO2010/93845 A1, 2010 ;
WO 2010/093845 A1
反应条件
sulfuric acid; water
7 h; Reflux;
参考文献
EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline, Eve; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin; WANG, Tie-lin
Patent: WO2010/93845 A1, 2010 ;
Location in patent: Page/Page column 160-161 ;
WO 2010/093845 A1
