1.1: sodium methylate; bromine / methanol / 0.5 h / 0 - 5 °C
1.2: 55 - 60 °C
2.1: hydrogenchloride / toluene / 3 h / 10 - 20 °C / |Inert atmosphere
3.1: sodium acetate / acetonitrile / 0.5 h / 20 °C
3.2: 1 h / 0 - 5 °C
4.1: acetic acid / toluene / 1 h / |Reflux
View Scheme
参考文献
Shapiro, Rafael; DiCosimo, Robert; Hennessey, Susan M.; Stieglitz, Barry; Campopiano, Onorato; Chiang, George C.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 593 - 598
1: 5-cyano-valeramide With bromine; sodium methylate in methanol
T=0 - 5°C; Hofmann Rearrangement; 0.5 h;
2: methanol T=55 - 60°C;
参考文献
Shapiro, Rafael; DiCosimo, Robert; Hennessey, Susan M.; Stieglitz, Barry; Campopiano, Onorato; Chiang, George C.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 593 - 598
