N-CBZ-beta-丙氨酸合成路线 （共 48 条）
反应条件
phosphorus tribromide in dichloromethane
24 h;
参考文献
Kolb, Juergen; Beck, Barbara; Doemling, Alexander
Tetrahedron Letters, 2002 , vol. 43, # 39 p. 6897 - 6901
参考文献
Birkofer; Modic
Justus Liebigs Annalen der Chemie, 1959 , vol. 628, p. 162,170
反应条件
dicyclohexyl-carbodiimide in dichloromethane
参考文献
Doherty; Livingston; Zeldes
Journal of the American Chemical Society, 1976 , vol. 98, # 24 p. 7717 - 7723
反应条件
1: DCC / CH2Cl2
2: (hydrolysis)
View Scheme
参考文献
Doherty; Livingston; Zeldes
Journal of the American Chemical Society, 1976 , vol. 98, # 24 p. 7717 - 7723
参考文献
Aebi, Johannes; Blum, Denise; Bur, Daniel; Chucholowski, Alexander; Dehmlow, Henrietta; Kitas, Eric Argirios; Loeffler, Bernd Michael; Obst, Ulrike; Wallbaum, Sabine
Patent: US2002/49243 A1, 2002 ;
反应条件
1-ethyl-piperidine; dicyclohexyl-carbodiimide in dichloromethane
1) -5 deg C; 2) 0 deg C, 2 h; 3) 12h, room temp.;
参考文献
Kasafirek, Evzen; Fric, Premysl; Slaby, Jan
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 6 p. 1625 - 1633
反应条件
dicyclohexyl-carbodiimide
参考文献
Okada; Iguchi; Okinaka; Yagyu; Sano; Otani
Chemical and Pharmaceutical Bulletin, 1978 , vol. 26, # 11 p. 3588 - 3591
反应条件
oxalyl dichloride in dichloromethane
T=25°C; 4 h;
参考文献
Yuan, Hai; Silverman, Richard B.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 5 p. 1331 - 1338
