N-苄氧羰基-L-天冬酰胺合成路线 （共 51 条）
反应条件
thionyl chloride in N,N-dimethyl-formamide T=-5°C; 3 h;
参考文献
Briere, Jean-Francois; Charpentier, Patricia; Dupas, Georges; Queguiner, Guy; Bourguignon, Jean
Tetrahedron, 1997 , vol. 53, # 6 p. 2075 - 2086
反应条件
sodium hydroxide; bromine in water T=55°C; Hofmann rearrangement; 3 h;
参考文献
Doyle, Michael P.; Colyer, John T.
Tetrahedron Asymmetry, 2003 , vol. 14, # 22 p. 3601 - 3604
反应条件
1: C6H5I(CF3COO)2, pyridine / H2O; dimethylformamide / 4.5 h / Ambient temperature 2: NaHCO3 / H2O; acetone / 3 h View Scheme
参考文献
Kazmierski, Wieslaw M.
Tetrahedron Letters, 1993 , vol. 34, # 28 p. 4493 - 4496
反应条件
sulfuric acid; acetic anhydride in acetic acid T=50°C; 1 h;
参考文献
Novabiochem AG
Patent: US5324833 A1, 1994 ;
反应条件
triethylamine in tetrahydrofuran
参考文献
Sondheimer,E.; Semeraro,R.J.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1847 - 1849
反应条件
diethyl cyanophosphonate; triethylamine in N,N-dimethyl-formamide 16 h; Ambient temperature; Yield given;
参考文献
Asagarasu, Akira; Uchiyama, Taketo; Achiwa, Kazuo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 4 p. 697 - 703
反应条件
1: 47 percent / [bis(trifluoroacetoxy)iodo]-benzene; pyridine / dimethylformamide; H2O / 4.5 h / 20 °C 2: 91 percent / Na2CO3 / H2O; dioxane / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 56, # 16 p. 2513 - 2522
反应条件
sodium hydroxide; chlorine
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 83, p. 1078 - 1082
反应条件
n-ethyl morpholine; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide in tetrahydrofuran
64 h; Ambient temperature;
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
