Nα-CBZ-Nω-硝基-L-精氨酸合成路线 （共 16 条）
反应条件
1: triethylamine; THF / anschliessendes Behandeln mit L-Phenylalanin-aethylester-hydrochlorid und Triaethylamin in CHCl3
2: aqueous acetone; aqueous NaOH
3: palladium; ethanol / Hydrogenation.weiteres Reagens: Essigsaeure
View Scheme
参考文献
Gibian,H.; Schroeder,E.
Justus Liebigs Annalen der Chemie, 1961 , vol. 642, p. 145 - 162
反应条件
2: aqueous acetone; aqueous NaOH
3: palladium; aqueous HCl; acetic acid / Hydrogenation
View Scheme
参考文献
Scopes,P.M. et al.
Journal of the Chemical Society, 1965 , p. 782 - 786
反应条件
2: aqueous NaOH
3: palladium; methanol; acetic acid / Hydrogenation
View Scheme
参考文献
Gibian,H.; Schroeder,E.
Justus Liebigs Annalen der Chemie, 1961 , vol. 642, p. 145 - 162
反应条件
1: Et3N, N-hydroxybenzotriazole, watersoluble carbodiimide / 18 h / 0 °C
2: HF, anisole-thioanisole-o-cresol / 0.5 h / ice-bath
View Scheme
参考文献
Abiko; Onodera; Sekino
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 8 p. 2507 - 2511
反应条件
1: (i) Et3N, THF, DMF, (ii) /BRN= 2548552/, DCC
2: H2 / Pd / methanol; acetic acid; H2O
View Scheme
参考文献
Gibian,H.; Schroeder,E.
Justus Liebigs Annalen der Chemie, 1961 , vol. 642, p. 145 - 162
反应条件
1: DCC
2: aq. NaOH
3: H2 / Pd-C / acetic acid
View Scheme
参考文献
Gibian,H.; Schroeder,E.
Justus Liebigs Annalen der Chemie, 1961 , vol. 642, p. 145 - 162
