5-甲氧基-苯并[B]噻吩-2-羧酸合成路线 （共 6 条）
反应条件
1: With water; sodium hydroxide in tetrahydrofuran T=0 - 20°C; 2 h; 2: With hydrogenchloride in water; ethyl acetate pH=2;
参考文献
MethylGene Inc.
Patent: US2010/279983 A1, 2010 ;
Location in patent: Page/Page column 23 ;
US 20100279983 A1
反应条件
N-chloro-succinimide in 1,4-dioxane
参考文献
LIFE TECHNOLOGIES CORPORATION; JUO, Rouh-Rong; BROOKS, Edward; GEE, Melissa; WANG, Zhixian H; SKAARE, Kathleen
Patent: WO2010/101839 A2, 2010 ;
Location in patent: Page/Page column 21-22 ;
反应条件
iodine in 1,4-dioxane 24 h; Heating;
参考文献
Faucher, Nicolas; Martres, Paul; Laroze, Alain; Pineau, Olivier; Potvain, Florent; Grillot, Didier
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 710 - 715
反应条件
potassium carbonate in acetonitrile T=20°C; Reflux; Product distribution / selectivity;
参考文献
LIFE TECHNOLOGIES CORPORATION; JUO, Rouh-Rong; BROOKS, Edward; GEE, Melissa; WANG, Zhixian H; SKAARE, Kathleen
Patent: WO2010/101839 A2, 2010 ;
Location in patent: Page/Page column 22-23 ;
反应条件
1: 5-(methoxy)-1-benzothiophene-2-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane Inert atmosphere; 2: methanol in dichloromethane T=20 - 40°C; Product distribution / selectivity;
参考文献
LIFE TECHNOLOGIES CORPORATION; JUO, Rouh-Rong; BROOKS, Edward; GEE, Melissa; WANG, Zhixian H; SKAARE, Kathleen
Patent: WO2010/101839 A2, 2010 ;
Location in patent: Page/Page column 22-23 ;
反应条件
quinoline; copper T=190°C; 1.5 h;
参考文献
MethylGene Inc.
Patent: US2010/279983 A1, 2010 ;
Location in patent: Page/Page column 23 ;
US 20100279983 A1
