5,6-二甲氧基-1-苯并噻吩-2-羧酸合成路线 （共 8 条）
反应条件
1: With water; sodium hydroxide in tetrahydrofuran; methanol T=20°C; 2: With hydrogenchloride in tetrahydrofuran; methanol; water pH=3;
参考文献
FIBROTECH THERAPEUTICS PTY LTD; WILLIAMS, Spencer John; ZAMMIT, Steven; KELLY, Darren James
Patent: WO2011/47432 A1, 2011 ;
Location in patent: Page/Page column 97 ;
反应条件
1: 18-crown-6 ether; potassium carbonate / N,N-dimethyl-formamide / 80 °C 2: water; sodium hydroxide / ethanol / 20 °C View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 3, # 7 p. 550 - 554
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 60 °C 2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C 2.2: pH 3 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 21, p. 32,35
反应条件
1: dibenzoyl peroxide; benzene / Lichtausschluss 2: dioxane; iodine View Scheme
参考文献
Journal of Organic Chemistry, , vol. 21, p. 32,35
反应条件
ethanol; sodium carbonate Erwaermen des Reaktionsprodukts mit wss.-methanol. Natronlauge und Erhitzen des Reaktionsgemisches mit wss. Natrium-chloracetat-Loesung;
参考文献
Journal of the Chemical Society, , p. 1314
反应条件
sulfuric acid in methanol
参考文献
Tsunoda, Hidetoshi; Fukuzawa, Nobuyuki; Chiba, Kyoko; Nakao, Toshifumi; Asada, Noriaki; Takebayashi, Nozomi; Kibayashi, Kenji; Migita, Hideyuki; Morikawa, Maki
Patent: US2003/109570 A1, 2003 ;
参考文献
Bew; Clemo
Journal of the Chemical Society, 1953 , p. 1314
Full Text Show Details
Campaigne; Cline
Journal of Organic Chemistry, 1956 , vol. 21, p. 32,35
