反-1,2-环己烷二甲酸合成路线 (共 51 条)
反应条件
1.1: ethanol / 6.5 h / -70 - 20 °C / Resolution of racemate 2.1: hydrogenchloride / water 3.1: sulfuric acid / 18 h / 40 °C 4.1: diisobutylaluminium hydride / toluene / 6 h / -5 - 20 °C / Inert atmosphere 4.2: 13 h / -5 - 40 °C 5.1: triethylamine / chloroform / 5 h / 0 - 20 °C View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shri Prakash Dhar; SINGH, Ramesh Chandra; CHAVDA, Rajendra Gokalbhai
Patent: WO2013/121440 A1, 2013 ;