4,5,6,7-四氰吲唑合成路线 （共 11 条）
反应条件
1: 86 percent / ethanol / 5 h / Heating 2: 39 percent / NaH / toluene / 7 h / Heating 3: 1.) KOH; 2.) CuCl2 / 1.) isopropanol, reflux, 14 h; 2.) 6M NH3, 5 deg C, 20 min 4: 2.) H2 / 2.) 20percent Pd-C / 1.) 350 deg C, 20 Torr; 2.) EtOAc, 2 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 107, p. 3686
反应条件
1: 39 percent / NaH / toluene / 7 h / Heating 2: 1.) KOH; 2.) CuCl2 / 1.) isopropanol, reflux, 14 h; 2.) 6M NH3, 5 deg C, 20 min 3: 2.) H2 / 2.) 20percent Pd-C / 1.) 350 deg C, 20 Torr; 2.) EtOAc, 2 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 107, p. 3686
反应条件
1: 1.) KOH; 2.) CuCl2 / 1.) isopropanol, reflux, 14 h; 2.) 6M NH3, 5 deg C, 20 min 2: 2.) H2 / 2.) 20percent Pd-C / 1.) 350 deg C, 20 Torr; 2.) EtOAc, 2 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 107, p. 3686
反应条件
hydrogen; palladium on activated charcoal 1.) 350 deg C, 20 Torr; 2.) EtOAc, 2 h; Yield given. Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 107, p. 3686
反应条件
1: in tetrahydrofuran T=20°C; 4 h; 2: With hydrazine hydrate in tetrahydrofuran T=20°C; 15 h;
参考文献
Katritzky; Denisenko; Arend
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 5 p. 1309 - 1314
反应条件
acetic acid; platinum Hydrogenation;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 550, p. 31,44
参考文献
Zhurnal Obshchei Khimii, , vol. 29, p. 2537,2540; engl. Ausg. S. 2499, 2502
反应条件
methanol; hydrazine hydrate
参考文献
Organic Syntheses, , vol. Coll. Vol. IV, p. 536,538
反应条件
T=610°C; other temperatures; Product distributionMechanism;
参考文献
Journal of Organic Chemistry, , vol. 56, # 17 p. 5101 - 5107
参考文献
Justus Liebigs Annalen der Chemie, , vol. 453, p. 234
