2-氯-5-硝基-4-甲基吡啶合成路线 （共 31 条）
反应条件
phosphorus pentachloride; trichlorophosphate T=150°C; 2 h;
参考文献
MERZ PHARMA GMBH and CO. KGAA; HENRICH, Markus; ABEL, Ulrich; MULLER, Sibylle; KUBAS, Holger; MEYER, Udo; HECHENBERGER, Mirko; KAUSS, Valerjans; ZEMRIBO, Ronalds
Patent: WO2012/52451 A1, 2012 ;
Location in patent: Page/Page column 117-118 ;
WO 2012/052451 A1
反应条件
copper dichloride in N,N-dimethyl-formamide T=60 - 110°C; 16.5 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/97129 A2, 2005 ;
Location in patent: Page/Page column 176-177 ;
WO 2005/097129 A2
反应条件
thionyl chloride in N-methyl-acetamide; dichloromethane; toluene
参考文献
Pfizer Inc.
Patent: US5051412 A1, 1991 ;
反应条件
1: concentrated H2SO4; concentrated HNO3 2: aqueous sulfuric acid; sodium nitrite / Diazotization 3: phosphorus (V)-chloride; phosphoryl chloride View Scheme
参考文献
Journal of the Chemical Society, , p. 2448,2455
反应条件
1: With sulfuric acid; nitric acid 2: With hydrogenchloride; sodium nitrite 3: With trichlorophosphate
参考文献
Journal of Fluorine Chemistry, , vol. 132, # 8 p. 541 - 547
反应条件
1: N,N-dimethyl-formamide / 2 h / 145 °C / Inert atmosphere 2: sodium periodate / tetrahydrofuran; water / 20 °C / Inert atmosphere 3: iron; acetic acid View Scheme
参考文献
Hou, Chuan-Jin; Guo, Wei-Lei; Liu, Xiao-Ning; Yang, Da-Wei
Heterocyclic Communications, 2011 , vol. 17, # 1-2 p. 21 - 23
反应条件
1: 50 percent / tetrahydrofuran / 8 h / -78 - -20 °C 2: 88 percent / H2 / aq. ethanol / 1551.49 - 2068.65 Torr View Scheme
参考文献
Zhang, Zhongxing; Yang, Zhong; Meanwell, Nicholas A.; Kadow, John F.; Wang, Tao
Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2345 - 2347
反应条件
1: acetic acid; sodium acetate; palladium/charcoal / Hydrogenation 2: ethyl nitrite; petroleum ether / Diazotization 3: KMnO4; H2O View Scheme
参考文献
Roe; Seligman
Journal of Organic Chemistry, 1955 , vol. 20, p. 1729,1731
反应条件
palladium on activated charcoal; sodium acetate; acetic acid Hydrogenation;
参考文献
Roe; Seligman
Journal of Organic Chemistry, 1955 , vol. 20, p. 1729,1731
反应条件
1.1: methanol / 5 h / Reflux 2.1: potassium tert-butylate / diethyl ether; ethanol / 0.25 h 2.2: Reflux 2.3: 2 h / 20 °C 3.1: hydrogen / palladium on carbon / ethanol / 24 h View Scheme
参考文献
LES LABORATOIRES SERVIER
Patent: US2011/112104 A1, 2011 ;
