2-氯-5-硝基-4-甲基吡啶合成路线 （共 31 条）
反应条件
1: in N,N-dimethyl-formamide T=90°C; 18 h; 2: With acetic acid; zinc T=0°C; 18 h; Inert atmosphere;
参考文献
WO2013/181075 A1, ;
Page/Page column 14; 15 ;
反应条件
in N,N-dimethyl-formamide T=90°C; 18 h; Inert atmosphere;
参考文献
Baxter, Ellen W.; Reitz, Allen B.; Parker, Michael H.; Huang, Yifang; Ho, Chih Yung; Strobel, Eric D.; Reynolds, Charles H.
Patent: US2007/232630 A1, 2007 ;
Location in patent: Page/Page column 22 ;
US 20070232630 A1
反应条件
in N,N-dimethyl-formamide T=90°C; 18 h;
参考文献
MERCK SHARP and DOHME CORP.; ALTMAN, Michael, D.; FISCHER, Christian; KATZ, Jason, D.; WILLIAMS, Theresa, M.; ZHANG, Xu-Fang; ZHOU, Hua
Patent: WO2013/181075 A1, 2013 ;
Location in patent: Page/Page column 14; 15 ;
反应条件
1: in N,N-dimethyl-formamide T=90°C; 18 h; 2: With acetic acid; zinc T=0°C; 18 h; Inert atmosphere;
参考文献
MERCK SHARP and DOHME CORP.; ALTMAN, Michael, D.; FISCHER, Christian; KATZ, Jason, D.; WILLIAMS, Theresa, M.; ZHANG, Xu-Fang; ZHOU, Hua
Patent: WO2013/181075 A1, 2013 ;
Location in patent: Page/Page column 14; 15 ;
反应条件
1.1: N,N-dimethyl-formamide / 18 h / 95 °C 2.1: sodium periodate / water; tetrahydrofuran / 6 h / 20 °C 3.1: titanium tetrachloride / dichloromethane; diethyl ether / 1 h / -78 - -50 °C 3.2: 1 h / -50 °C 4.1: Dess-Martin periodane / dichloromethane / 16 h 5.1: acetic acid; iron / 4 h View Scheme
反应条件
1.1: N,N-dimethyl-formamide / 18 h / 95 °C 2.1: sodium periodate / water; tetrahydrofuran / 6 h / 20 °C 3.1: titanium tetrachloride / dichloromethane; diethyl ether / 1 h / -78 - -50 °C 3.2: 1 h / -50 °C 4.1: Dess-Martin periodane / dichloromethane / 16 h View Scheme
参考文献
Burger, Matthew; Lindvall, Mika
Patent: US2011/195980 A1, 2011 ;
反应条件
1: tin(II) chloride, conc. hydrochloric acid / diethyl ether / Heating
2: 5.2 g / toluene / 2 h / 100 °C
View Scheme
参考文献
Chapman, David; Hurst, Jim
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2398 - 2404
反应条件
1: With 1,8-diazabicyclo[5.4.0]undec-7-ene
T=20°C; Inert atmosphere;
2: With hydrogenchloride in water
参考文献
JANSSEN RandD IRELAND; COOYMANS, Ludwig Paul; DEMIN, Samuel Dominique; HU, Lili; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; TAHRI, Abdellah; VENDEVILLE, Sandrine Marie Helene
Patent: WO2012/80450 A1, 2012 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1: oxalic acid diethyl ester With potassium ethanolate in diethyl ether; ethanol
T=20°C; 0.5 h;
2: 2-chloro-4-methyl-5-nitropyridine in diethyl ether; ethanol
T=20°C; 15 h;
参考文献
Prosidion Ltd
Patent: WO2006/67532 A1, 2006 ;
Location in patent: Page/Page column 19 ;
WO 2006/067532 A1
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane
12 h; Heating / reflux;
参考文献
SANOFI-AVENTIS
Patent: US2008/125459 A1, 2008 ;
Location in patent: Page/Page column 15 ;
