4-氯-2-甲基-3-硝基吡啶合成路线 （共 7 条）
反应条件
1: H2 / PtO2 / acetic acid / 2068.6 Torr 2: 40 percent / HNO3, NaNO2 / H2O / <20 deg C 3: HNO3, H2SO4 / 2 h / Heating 4: 26.7 g / POCl3 / 2 h / Heating View Scheme
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
反应条件
in dichloromethane; trichlorophosphate
参考文献
Merck and Co., Inc.
Patent: US5496816 A1, 1996 ;
反应条件
1: 40 percent / HNO3, NaNO2 / H2O / <20 deg C 2: HNO3, H2SO4 / 2 h / Heating 3: 26.7 g / POCl3 / 2 h / Heating View Scheme
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
反应条件
trichlorophosphate 2 h; Heating;
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
反应条件
1: HNO3, H2SO4 / 2 h / Heating 2: 26.7 g / POCl3 / 2 h / Heating View Scheme
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
反应条件
1: N2H4*H2O / ethanol / 1.) 0 deg C, 0.75 h, 2.) 25 deg C, 3.5 h 2: H2 / 5percent Pd/C / aq. ethanol 3: conc. HCl / 2.5 h 4: MnO2, 5 M NaOH / H2O / 0.83 h / pH 6 View Scheme
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
反应条件
1: ethanol / 5 h / Heating 2: H2, HCl / 5percent Pd/C / aq. ethanol / 2327.2 Torr 3: HCl / ethanol / 1.) 25 deg C, 5 h, 2.) reflux, 1.5 h 4: MnO2, 5 M NaOH / H2O / 0.83 h / pH 6 View Scheme
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
